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Increased Cervical CD4 + CCR5 + T Cells Among Kenyan Sex Working Women Using Depot Medroxyprogesterone Acetate
(University of Nairobi, 2019)
Depot medroxyprogesterone acetate (DMPA) is the most common hormonal contraceptive used by women in sub-
Saharan Africa, however, it has been epidemiologically associated with HIV infections. To assess whether DMPA
has ...
Intimate partner and client-perpetrated violence are associated with reduced HIV pre-exposure prophylaxis (PrEP) uptake, depression and generalized anxiety in a cross-sectional study of female sex workers from Nairobi, Kenya
(University of Nairobi, 2021-06)
Introduction: UNAIDS has identified female sex workers (FSW) as a key HIV at-risk population. FSW disproportionately experience gender-based violence, which compounds their risk of HIV acquisition and may contribute to ...
Differential Elevation of Inflammation and CD4+ T Cell Activation in Kenyan Female Sex Workers and Non-Sex Workers Using Depot-Medroxyprogesterone Acetate.
(University of Nairobi, 2021)
Background
Depot Medroxyprogesterone (DMPA) is one of the most widely used contraceptives in Sub-Saharan Africa where HIV incidence is high. We explored the effect of DMPA on the activation of HIV cellular targets and ...
Willingness to participate in future HIV vaccine trials among men who have sex with men and female sex workers living in Nairobi, Kenya
(University of Nairobi, 2020)
Objective
To evaluate factors associated with willingness to participate in future HIV vaccine trials among men who have sex with men and female sex workers living in Nairobi, Kenya.
Background
Working with ‘key ...
Characterization of occult hepatitis B in high-risk populations in Kenya
(University of Nairobi, 2020)
Occult hepatitis B infection (OBI) is defined as the presence of hepatitis B virus (HBV) DNA in the liver or serum in the absence of detectable HBV surface antigen (HBsAg). OBI poses a risk for the development of cirrhosis ...
The effects of COVID-19 on the health and socio-economic security of sex workers in Nairobi, Kenya: Emerging intersections with HIV
(University of Nairobi, 2020)
The COVID-19 pandemic, and its attendant responses, has led to massive health, social, and economic challenges on a global scale. While, so far, having a relatively low burden of COVID-19 infection, it is the response in ...
High level of plasma TILRR protein is associated with faster HIV seroconversion
(University of Nairobi, 2022-04)
Background: TILRR (Toll-like Interleukin-1 Receptor Regulator) is a modulator of many genes in NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) signaling. It promotes the production of inflammatory ...
Multi-omics analysis of the cervical epithelial integrity of women using depot medroxyprogesterone acetate
(University of Nairobi, 2022-05)
Depot medroxyprogesterone acetate (DMPA) is an injectable hormonal contraceptive used by millions of women worldwide. However, experimental studies have associated DMPA use with genital epithelial barrier disruption and ...
High Level of Pre-Treatment HIV-1 Drug Resistance and Its Association with HLA Class I-Mediated Restriction in the Pumwani Sex Worker Cohort
(University of Nairobi, 2022-01)
Background: We analyzed the prevalence of pre-antiretroviral therapy (ART) drug resistance mutations (DRMs) in a Kenyan population. We also examined whether host HLA class I genes influence the development of pre-ART ...