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Associations Of Human Leukocyte Antigen-g With Resistance And Susceptibility To Hiv-1 Infection In The Pumwani Sex Worker Cohort.
(University of Nairobi, 2013-01)
OBJECTIVE:
To determine the association between human leukocyte antigens (HLA)-G genotypes and resistance or susceptibility to HIV-1.
DESIGN:
A group of sex workers in Pumwani, Kenya can be epidemiologically defined ...
Molecular Definition Of Vaginal Microbiota In East African Commercial Sex Workers
(University of Nairobi, 2011-06)
Resistance to HIV infection in a cohort of commercial sex workers living in Nairobi, Kenya, is linked to mucosal and antiinflammatory factors that may be influenced by the vaginal microbiota. Since bacterial vaginosis (BV), ...
Anti-HIV-1 activity of elafin depends on its nuclear localization and altered innate immune activation in female genital epithelial cells.
(University of Nairobi, 2012-12-27)
Elafin (E) and its precursor trappin-2 (Tr) are alarm antiproteases with antimicrobial and immunomodulatory activities. Tr and E (Tr/E) have been associated with HIV-1 resistance. We recently showed that Tr/E reduced IL-8 ...
Mucosal Serpin A1 And A3 Levels In Hiv Highly Exposed Sero-negative Women Are Affected By The Menstrual Cycle And Hormonal Contraceptives But Are Independent Of Epidemiological Confounders.
(University of Nairobi, 2013-01)
OBJECTIVE:
Serpins (serine protease inhibitors) are associated with protection against HIV infection. Here, we characterized mucosal serpin expression in the genital tract of HIV highly exposed sero-negative (HESN) women ...