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Stable CD4 Expression and Local Immune Activation in the Ectocervical Mucosa of HIV-Infected Women.
(2013)
Studies using genital tissue samples from HIV-infected women might provide important information about HIV susceptibility and transmission. In this study, ectocervical biopsies were obtained from 20 HIV-seropositive (HIV(+)) ...
Optimizing viable leukocyte sampling from the female genital tract for clinical trials: an international multi-site study
(University of Nairobi, 2014)
BACKGROUND:
Functional analysis of mononuclear leukocytes in the female genital mucosa is essential for understanding the immunologic effects of HIV vaccines and microbicides at the site of HIV exposure. However, the ...
Early HIV-1 Infection Is Associated With Reduced Frequencies of Cervical Th17 Cells.
(2015)
BACKGROUND::
The hallmark of HIV infection is progressive but variable rates of systemic and mucosal CD4 depletion, leading to immunodeficiency. The impact of early HIV infection on cervical CD4 T-cell populations in ...
Characterization of a human cervical CD4+ T cell subset coexpressing multiple markers of HIV susceptibility
(2011)
The HIV pandemic disproportionately affects women, with most infections acquired through receptive vaginal sex. Although the target cells by which HIV establishes infection in the female genital tract remain poorly defined, ...
Association of sex work with reduced activation of the mucosal immune system
(University of Nairobi, 2014-01)
Background. Unprotected intercourse and seminal discharge are powerful activators of the mucosal immune system and are an important risk factors for HIV transmission. This study was designed to determine if female sex work ...
HIV-infected women have high numbers of CD103-CD8+ T cells residing close to the basal membrane of the ectocervical epithelium.
(University of Nairobi, 2017)
BACKGROUND:
Genital mucosa is the main portal of entry for various incoming pathogens, including HIV, hence an important site for host immune defenses. Tissue-resident memory T (TRM) cells defend tissue barriers against ...
Hiv-specific Cd8+ T-cell Proliferation Is Prospectively Associated With Delayed Disease Progression.
(University of Nairobi, 2012-03)
Human immunodeficiency virus (HIV)-specific CD8(+) T-cell proliferation is consistently correlated with enhanced host HIV immune control, but whether proliferative responses are a cause or consequence of immune protection ...
Impact of Standard Bacterial Vaginosis Treatment on the Genital Microbiota, Immune Milieu, and Ex Vivo Human Immunodeficiency Virus Susceptibility.
(Oxford Academic, 2018-09-12)
BACKGROUND:
Genital immunology is a key determinant of human immunodeficiency virus (HIV) susceptibility. Both factors are modulated by bacterial vaginosis (BV) and, to some extent, by Lactobacillus iners, the genital ...