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Epigenetic Control Of Irf1 Responses In HIV-exposed Seronegative Versus HIV-susceptible Individuals.
(University of Nairobi, 2011-03)
Not all individuals exposed to HIV become infected. Understanding why these HIV-exposed seronegative individuals remain uninfected will help inform the development of preventative measures against HIV infection. Interferon ...
Reducing IRF-1 to levels observed in HESN subjects limits HIV replication, but not the extent of Host immune activation.
(University of Nairobi, 2015-10)
Cells from women who are epidemiologically deemed resistant to HIV infection exhibit a 40–60% reduction in endogenous IRF-1
(interferon regulatory factor-1), an essential regulator of host antiviral immunity and the early ...