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Acting Locally: Innate Mucosal Immunity In Resistance To Hiv-1 Infection In Kenyan Commercial Sex Workers.
(University of Nairobi, 2013-06)
Cohort studies of female commercial sex workers (CSWs) in Kenya were among the first to identify highly HIV-1-exposed seronegative (HESN) individuals. As natural resistance is usually mediated by innate immune mechanisms, ...
Immunogenicity Of Sequences Around Hiv-1 Protease Cleavage Sites: Potential Targets And Population Coverage Analysis For A Hiv Vaccine Targeting Protease Cleavage Sites.
(University of Nairobi, 2013-06)
Developing an effective preventative vaccine against HIV-1 has proved to be a great challenge. The classical and proven vaccine approach has failed so far or produced a modest effect, new approaches are needed. In this ...
A distinct cytokine and chemokine profile at the genital mucosa is associated with HIV-1 protection among HIV-exposed seronegative commercial sex workers
(University of Nairobi,, 2012)
The predominance of HIV-1 sexual transmission requires a greater understanding of the interaction between HIV-1 and the mucosal immune system. The study of HIV-1-exposed seronegative (HESN) individuals serves as a model ...
Hiv-specific Cd8+ T-cell Proliferation Is Prospectively Associated With Delayed Disease Progression.
(University of Nairobi, 2012-03)
Human immunodeficiency virus (HIV)-specific CD8(+) T-cell proliferation is consistently correlated with enhanced host HIV immune control, but whether proliferative responses are a cause or consequence of immune protection ...