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Immunogenicity Of Sequences Around Hiv-1 Protease Cleavage Sites: Potential Targets And Population Coverage Analysis For A Hiv Vaccine Targeting Protease Cleavage Sites.
(University of Nairobi, 2013-06)
Developing an effective preventative vaccine against HIV-1 has proved to be a great challenge. The classical and proven vaccine approach has failed so far or produced a modest effect, new approaches are needed. In this ...
Altered Dendritic Cell-natural Killer Interaction In Kenyan Sex Workers Resistant To Hiv-1 Infection.
(University of Nairobi, 2012-02)
BACKGROUND:
Natural killer (NK) cells are members of the innate immune system that play an important role in the defense against viral infection. They are also involved in the regulation of adaptive immune responses ...
Assessment of the Feasibility of a Different HIV Vaccine Approach
(University Of Nairobi, 2011)
Background: The failure of Merck STEP and Phambili trials and
the modest effect of RV144 trial emphasize the importance of
understanding the correlates of protective immunity. Our study
showed that the epitope recognition ...
Characterization of a human cervical CD4+ T cell subset coexpressing multiple markers of HIV susceptibility
(2011)
The HIV pandemic disproportionately affects women, with most infections acquired through receptive vaginal sex. Although the target cells by which HIV establishes infection in the female genital tract remain poorly defined, ...
Association of sex work with reduced activation of the mucosal immune system
(University of Nairobi, 2014-01)
Background. Unprotected intercourse and seminal discharge are powerful activators of the mucosal immune system and are an important risk factors for HIV transmission. This study was designed to determine if female sex work ...
Regulation of mucosal and systemic immune activation during the menstrual cycle of female sex workers from nairobi, kenya; local regulation and HIV-induced impairment
(University of Nairobi, 2015)
Problem:
Vaginal intercourse is the main route of HIV infection among women. To result in a productive infection, HIV must encounter activated targets that sustain replication. Sexual hormones modulate activation and ...