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Using safe, affordable and accessible non-steroidal anti-inflammatory drugs to reduce the number of HIV target cells in the blood and at the female genital tract.
(University of Nairobi, 2018)
INTRODUCTION:
At its basic level, HIV infection requires a replication-competent virus and a susceptible target cell. Elevated levels of vaginal inflammation has been associated with the increased risk of HIV infection ...
High-risk HPV-RNA screening of physician- and self-collected specimens for detection of cervical lesions among female sex workers in Nairobi, Kenya.
(University of Nairobi, 2018)
OBJECTIVE:
To compare accuracy of detecting high-grade cervical lesions (squamous intraepithelial lesions or greater, HSIL+) by high-risk HPV messenger RNA (hrHPV-RNA) testing between physician- and self-collected ...
CD161 identifies polyfunctional Th1/Th17 cells in the genital mucosa that are depleted in HIV-infected female sex workers from Nairobi, Kenya.
(University of Nairobi, 2017)
CD161 identifies a subset of circulating Th17 cells that are depleted in the blood and gut of HIV-infected individuals. In the female reproductive tract (FRT), the pattern of CD161 expression on CD4+ cells remains unknown. ...
Subtype-specific differences in gag-protease-driven replication capacity are consistent with inter-subtype differences in hiv-1 disease progression.
(University of Nairobi, 2017)
There are marked differences in the spread and prevalence of HIV-1 subtypes worldwide, and differences in clinical progression have been reported. However, the biological reasons underlying these differences are unknown. ...
Improving adherence to post-cervical biopsy sexual abstinence in kenyan female sex workers.
(University of Nairobi, 2016)
PROBLEM:
Cervical biopsies offer a unique opportunity for studying local immune response. To investigate hormonally induced immune fluctuations in cervical tissues of Kenyan female sex workers, we improved biopsy sampling ...
HIV-infected women have high numbers of CD103-CD8+ T cells residing close to the basal membrane of the ectocervical epithelium.
(University of Nairobi, 2017)
BACKGROUND:
Genital mucosa is the main portal of entry for various incoming pathogens, including HIV, hence an important site for host immune defenses. Tissue-resident memory T (TRM) cells defend tissue barriers against ...
The incidence of first-line antiretroviral treatment changes and related factors among HIV-infected sex workers in Nairobi, Kenya.
(University of Nairobi, 2017)
INTRODUCTION:
In many settings, several factors including adverse drug reactions and clinical failure can limit treatment choices for combined antiretroviral therapy (cART). The aim of the study was to describe the incidence ...
Genetic markers associated with resistance to beta-lactam and quinolone antimicrobials in non-typhoidal salmonella isolates from humans and animals in central Ethiopia.
(University of Nairobi, 2016)
INTRODUCTION:
Several risk factors including stavudine and age have been strongly associated with polyneuropathy. However, conflicting data exist on height as an independent risk factor in polyneuropathy. The objective ...
Prevalent neuropathy in a cohort of HIV-infected Kenyan sex workers using antiretroviral drugs.
(University of Nairobi, 2016)
INTRODUCTION:
Several risk factors including stavudine and age have been strongly associated with polyneuropathy. However, conflicting data exist on height as an independent risk factor in polyneuropathy. The objective ...
Sexual Assault and HIV Postexposure Prophylaxis at an Urban African Hospital.
(University of Nairobi, 2017)
Antiretroviral postexposure prophylaxis (PEP) may be underutilized in sexual assault cases in Kenya. This study evaluated the characteristics of survivors of sexual violence attending the Gender-Based Violence Recovery ...