Browsing Faculty of Agriculture & Veterinary Medicine (FAg / FVM) by Author "Namikawa, Kuzuhiko"
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Cloning, Expression, and Characterization of Babesia gibsoni Dihydrofolate Reductase-Thymidylate Synthase: Inhibitory Effect of Antifolates on Its Catalytic Activity and Parasite Proliferation
Aboge, Gabriel O; Terkawi, Mohamad A; Goo, Youn-Kyoung; Nishikawa, Yoshifumi; Sunaga, Fujiko; Namikawa, Kuzuhiko; Tsuji, Naotoshi; Igarashi, Ikuo; Suzuki, Hiroshi; Fujisaki, Kozo; Xuan, Xuenan (Department of Public Health Pharmacology and Toxicology, 2008)Dihydrofolate reductase-thymidylate synthase (DHFR-TS) is a well-validated antifolate drug target in certain pathogenic apicomplexans, but not in the genus Babesia, including Babesia gibsoni. Therefore, we isolated, cloned, ...