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Cloning, Expression, and Characterization of Babesia gibsoni Dihydrofolate Reductase-Thymidylate Synthase: Inhibitory Effect of Antifolates on Its Catalytic Activity and Parasite Proliferation
(2008)
Dihydrofolate reductase-thymidylate synthase (DHFR-TS) is a well-validated antifolate drug target in certain pathogenic apicomplexans, but not in the genus Babesia, including Babesia gibsoni. Therefore, we isolated, cloned, ...
Babesia gibsoni: Serodiagnosis of infection in dogs by an enzyme-linked immunosorbent assay with recombinant BgTRAP
(2008)
The thrombospondin-related adhesive protein of Babesia gibsoni (BgTRAPJ is known as an immunodominant antigen and is, there¬fore, considered as a candidate for the developmentof a diagnostic reagent for canine babesiosis. ...
Identification of Secreted Antigen 3 from Babesia gibsoni
(2009)
A cDNA expression library of Babesia gibsoni was screened with the serum collected from a dog experimentally infected with B. gibsoni. A novel antigen sharing homology with secreted antigen 1 of B. gibsoni was isolated. ...
Molecular and immunological characterization of Babesia gibsoni
(2009)
Serological immune screening was used to identify a gene encoding heat shock protein-70 from Babesia gibsoni (BgHSP-70) that showed high homology with HSP-70s from other apicomplexan parasites. This gene corresponded to a ...
Identification of a novel B. gibsoni 27-kDa protein as a serodiagnostic antigen
(2008)
A novel gene encoding 27-kDa protein was identified by the screening of Babesia gibsoni cDNA library
with acutely infected dog serum. The BgP27 is a single copy gene with a predicted open reading frame of
762 bp and 254 ...
Molecularand immunological characterization of Babesia gibsoni and Babesia microti heat shockprotein-70
(2009)
Serological immunoscreening was used to identify a gene
encoding heat shock protein-70 from Babesia gibsoni
(BgHSP-70) that showed high homology with HSP-70s
from other apicomplexan parasites. This gene corresponded
to ...