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Host cell responses of Salmonella typhimurium infected human dendritic cells
(2006)
Live attenuated Salmonella are attractive vaccine candidates for mucosal application because they
induce both mucosal immune responses and systematic immune responses. After breaking the epithelium barrier,
Salmonella ...
Genetic background of attenuated Salmonella typhimurium has profound influence on infection and cytokine patterns in human dendritic cells
(2001)
Salmonella typhimurium (ST) can cause infection in man, and attenuated strains are under consideration as live vaccine vectors. However, little is known about the interaction of ST with human dendritic cells (DC). Here, ...
Salmonella virulence factor SipB induces activation and release of IL-18 in human dendritic cells
(2002)
Interleukin-18 (IL-18) plays an important
role in innate and acquired immunity, in particular
against intracellular pathogens. However,
little is known about the microbial factors that
trigger IL-18 secretion by dendritic ...
Human alveolar macrophages infected by virulent bacteria expressing SipB are a major source of active interleukin-18
(2003)
Recent publications have demonstrated that the protease caspase-1 is responsible for the processing of prointerleukin
18 (IL-18) into the active form. Studies on cell lines and murine macrophages have shown that the
bacterial ...