Browsing Faculty of Science & Technology (FST) by Author "Ndakala, Albert J"
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Article Preparation and Properties of 2-Methyleneoxetanes
Dollinger, Lisa M; Ndakala, Albert J; Hashemzadeh, Mehrnoosh; Wang, Gan; Wang, Ying; Martinez, Isamir; Arcari, Joel T; Galluzzo, David J; Howell, Amy R (American Chemical SocietyDepartment of Chemistry,, 1999)The methylenation of β-lactones 5 with dimethyltitanocene provides a versatile, reliable, and highly chemoselective entry to 2-methyleneoxetanes 7. The conversion proceeds selectively in the presence of alkenes, unprotected ... -
Directed Ring-Opening of 1,5-Dioxaspiro[3.2]hexanes: Selective Formation of 2,2-Disubstituted Oxetanes
Taboada, Rosa; Ordonio, Grace G; Ndakala, Albert J; Howell, Amy R (Department of Chemistry, University of Nairobi, 2003)1,5-Dioxaspiro[3.2]hexanes undergo ring-opening reactions with many heteroatom nucleophiles to provide α-substituted-β‘-hydroxy ketones. However, certain Lewis acidic nucleophiles provide 2,2-disubstituted oxetanes. Herein, ... -
Synthesis of a pyrrolidine derivative of a carvotacetone and monoterpenes for anti-methicillin-resistant Staphylococcus aureus and anti-cryptococcal properties
Masila, Veronica M; Ndakala, Albert J; Midiwo, Jacob O; Byamukama, Robert; Kamau, Rahab W; Kumarihamy, Mallika; Muhammad, Ilias (University of Nairobi, 2022-05)Monoterpene derivatives are of great biological relevance in the pharmaceutical industry. In the present study, pyrrolidine derivative of a carvotacetone, 3-O-benzylcarvotacetone (1), and selected monoterpenes (3-hydroxy ...