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Inhibition of c-Kit, VEGFR-2 (KDR), and ABCG2 by analogues of OSI-930
(2011)
The quinoline domain of OSI-930, a dual inhibitor of receptor tyrosine kinases (RTKs) c-Kit and KDR, was modified in an effort to further understand the SAR of OSI-930, and the binding site characteristics of c-Kit and ...
Serum 2-hydroxyglutarate levels predict isocitrate dehydrogenase mutations and clinical outcome in acute myeloid leukemia
(2013)
Cancer-associated isocitrate dehydrogenase (IDH) mutations produce the metabolite 2-hydroxyglutarate (2HG), but the clinical utility of 2HG has not been established. We studied whether 2HG measurements in acute myeloid ...
Magnitude and Direction of Thermal Diffusion of Colloidal Particles Measured by Thermal Field-Flow Fractionation
(2003-10)
In this paper we provide experimental evidence showing that various types of submicrometer-sized particles (latexes, inorganic, and metallic), suspended in either aqueous or nonaqueous carrier liquids to which a temperature ...
CD25 expression status improves prognostic risk classification in AML independent of established biomarkers: ECOG phase 3 trial, E1900
(2012)
We determined the prognostic relevance of CD25 (IL-2 receptor-α) expression in 657 patients (≤ 60 years) with de novo acute myeloid leukemia (AML) treated in the Eastern Cooperative Oncology Group trial, E1900. We identified ...
The role of mutations in epigenetic regulators in myeloid malignancies
(2012)
The role of mutations in epigenetic regulators in myeloid malignancies.
Recent genomic studies have identified novel recurrent somatic mutations in patients with myeloid malignancies, including myeloproliferative ...
Flavonoids and isoflavonoids of Erythrina burttii
(2009)
From the stem bark and root bark of Erythrina burttii twenty-three flavonoids and isoflavonoids, including some
eight new compounds, have been isolated and characterised. The stem bark of this plant mainly produces
isoflavanones ...
Synthesis and characterization of redox-active Complexes of molybdenum(ll) nitrosyl linked to pfunctionalized Iron(iii)-schiff bases
(University of Nairobi, 2011)
Characterization of heterobinuclear complexes containing molybdenum(II) nitrosyl metal fragment, Mo(NO)Tp'Cl;
r,' = tris(3,5-dimethylpyrazolyl) borate linked to p-functionalized Fe(Salen)Cl; by IR, UV, MS and elemental
analysis ...
The effects of maternal and infant vitamin A supplementation on vitamin A status: a randomised trial in Kenya.
(2007)
Postpartum vitamin A supplementation of mothers and infants is recommended, but the efficacy has been questioned. In this double-blind, placebo-controlled trial, Kenyan mother-infant pairs were randomised to maternal vitamin ...
Assessing family planning service-delivery skills in Kenya.
(University of Nairobi, 1997-06)
This report demonstrates the use of Lot Quality Assurance Sampling (LQAS) to evaluate the technical competence of two cohorts of family planning service providers in Kenya trained with a new curriculum. One cohort had just ...
Pre-selection of markers for genomic selection.
(University of Nairobi, 2011)
BACKGROUND:
Accurate prediction of genomic breeding values (GEBVs) requires numerous markers. However, predictive accuracy can be enhanced by excluding markers with no effects or with inconsistent effects among crosses ...