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6α-Hydroxy-α-toxicarol and (+)-tephrodin with antiplasmodial activities from Tephrosia species
(Elsevier, 2014)
The CH2Cl2/MeOH (1:1) extract of the roots of Tephrosia villosa showed good antiplasmodial activity against the chloroquine-sensitive (D6) and chloroquine-resistant (W2) strains of Plasmodium falciparum with IC50 values ...
Variability of surface exudates of dodonaea angustifolia l.F, antioxidant and antiplasmodial activities of the compounds
(University of Nairobi, 2016)
Dodonaea angustifolia L.f is a medicinal plant used in the Kenyan traditional system of medicine to cure human diseases. The secondary metabolites present in the surface exudates, showed phytochemical diversity of this ...
Pyrazole, isoxazoline and bypyrimidine derivatives from polygonum senegalense and psiadia punctulata flavonoids and their anti- microbial activities
(University of Nairobi, 2017)
Currently, researchers have given special attention to the synthesis of hetero
cyclic compounds with nitrogen and oxygen five in five or six
membered
ring systems. This is mainly due to their wide range of biological ...
Semi-synthetic pyrazoline derivatives from polygonum senegalense chalcones and their anti-microbial activities
(University of Nairobi, 2017)
This paper describes the semi-synthesis and anti-microbial activity of novel
pyrazoline derivatives of
Polygonum senegalense
chalcones. The study
was carried out on the understanding that heterocycles ...
Antiplasmodial Activities Of The Stem Bark Extract And Compounds Of Zanthoxylum Gilletii (De Wild) P.G. Waterman
(University of Nairobi, 2017)
Introduction:
Multidrug resistance remains a major obstacle hindering
successful antimalarial chemotherapy. In the current study, 50% metha
-
nol in dichloromethane extract and six compounds from the ...
Inhibition of Proinflammatory Cytokine Release by Flavones and Flavanones from the Leaves of Dracaena steudneri Engl
(University of Nairobi, 2021-03)
The leaves of Dracaena steudneri yielded 6 new flavonoids-3,5,7-trihydroxy-6-methyl-3',4'-methylenedioxyflavone (1: ), 5,7-dihydroxy-3-methoxy-6-methyl-3',4'-methylenedioxyflavone (2: ), 3,5,7-trihydroxy-6-methoxy-3',4'- ...
Two new flavonoids from Dracaena usambarensis Engl.
(University of Nairobi, 2020)
Investigations of the root extract of Dracaena usambarensis Engl. for anticancer principles led to the characterization of one new homoisoflavonoid, (3S)-3,4ʹ,5,6-tetrahydroxy-7-methoxyhomoisoflavanone (1) and a new ...
Anti-leishmanial activity of some surface compounds of Tarchonanthus camphoratus
(University of Nairobi, 2019)
Background: The World Health Organization recognizes leishmaniasis as a major tropical disease with no effective vaccine against it.
Chemotherapy, the only effective way to treat all forms of the disease, is toxic and ...
Antiproliferative Properties of Labdane Diterpenoids from Croton sylvaticus Hochst against Drug Sensitive and Resistant Leukemia cell lines
(University of Nairobi, 2019)
Background: Cancer treatment failure is majorly attributed to the emergency of multi-drug resistance of cancer cells towards most conventional
drugs used in chemotherapy hence the need for more active principles with less ...
Anti-vancomycin-resistant Enterococcusfaecium and E. faecalis ACTIVITIES of (-)-gossypol and derivatives from Thespesia garckeana.
(2015)
The root extract of Thespesia garckeana yielded three known oxidatively coupled sesquiterpenoids, namely (-)-gossypol (1) and two of its derivatives (-)-6-methoxygossypol (2) and (+)-6,6'-dimethoxygossypol (3), and the ...