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Solid-phase peptide synthesis of isotocin with amide of asparagine protected with 1-tetralinyl. Rifluoromethanesulphonic acid (tfmsa) deprotection, cleavage and air oxidation of mercapto groups to disulphide
(2001)
Isotocin, a nonapept ide amide, was synthesised on a benzhydryl-resin using the Bocst
rat egy. Benzyl group was used in the pr otect ion of the side-ch ains of tyrosine, ser ine and cyst eine.
Tetr alinyl group was used ...
A New Approach to Search for the Bioactive Conformation of Glucagon: Positional Cyclization Scanning
(2001-09)
In search for the bioactive conformation of glucagon, “positional cyclization scanning” was used to determine secondary structures of glucagon required for maximal interaction with the glucagon receptor. Because glucagon ...