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Transcriptional profiling of inflammatory cytokine genes in African buffaloes (Syncerus caffer) infected with Theileria parva
(University of Nairobi, 2012-08)
Theileria parva (T. parva) causes East Coast fever (ECF), which is of huge economic importance to Eastern and Southern African countries. In a previous bovine model, inflammatory cytokines were closely associated with ...
Molecular detection and characterization of potentially new Babesia and Theileria species/variants in wild felids from Kenya
(University of Nairobi, 2012-10)
Piroplasms frequently infect domestic and wild carnivores. At present, there is limited information on the occurrence and molecular identity of these tick-borne parasites in wild felids in Kenya. In 2009, a pair of captive ...
Prognostic relevance of integrated genetic profiling in acute myeloid leukemia
(2012)
BACKGROUND:
Acute myeloid leukemia (AML) is a heterogeneous disease with respect to presentation and clinical outcome. The prognostic value of recently identified somatic mutations has not been systematically evaluated ...
How do novel molecular genetic markers influence treatment decisions in acute myeloid leukemia?
(2012)
Acute myeloid leukemia (AML) is the most common acute leukemia diagnosed in adults, and the majority of patients with AML die from relapsed disease. Although many studies over the past 4 decades have identified disease ...
Anthraquinones of the roots of Pentas micrantha
(University of Nairobi, 2012-12)
Pentas micrantha is used in the East African indigenous medicine to treat malaria. In the first investigation of this plant, the crude methanol root extract showed moderate antiplasmodial activity against the W2- (3.37 ...
Study on the microstructure of African wild silk cocoon shells and fibers
(2012-01)
Silk fibers and cocoon shells from four African wild silkmoths Gonometa postica, Anaphe panda, Argema mimosae and Epiphora bauhiniae-were studied to gain insight into the structure-property-function relations and potential ...
Steady rifting in northern Kenya inferred from deformed Holocene lake shorelines of the Suguta and Turkana basins.
(University of Nairobi, 2012-05-15)
A comparison of deformation rates in active rifts over different temporal scales may help to decipher variations in their structural evolution, controlling mechanisms, and evolution of sedimentary environments through time. ...
ASXL1 mutations promote myeloid transformation through loss of PRC2-mediated gene repression
(2012)
Recurrent somatic ASXL1 mutations occur in patients with myelodysplastic syndrome, myeloproliferative neoplasms, and acute myeloid leukemia, and are associated with adverse outcome. Despite the genetic and clinical data ...
Effect of serum lipoproteins on stereoselective halofantrine metabolism by rat hepatocytes
(2012)
Experimental hyperlipidemia has shown to decrease cytochrome P450 3A4 and 2C11 expression and to increase liver concentrations and the plasma protein binding of halofantrine (HF) enantiomers. The present study examined the ...