dc.contributor.author | Ngure, R. M | |
dc.contributor.author | Ndungu, JM | |
dc.contributor.author | Ngotho, J M | |
dc.contributor.author | Nancy, M K | |
dc.contributor.author | Maathai, R G | |
dc.contributor.author | Gateri, L M | |
dc.date.accessioned | 2015-02-13T07:57:11Z | |
dc.date.available | 2015-02-13T07:57:11Z | |
dc.date.issued | 2008-05-16 | |
dc.identifier.citation | Ngure, R. M., Ngotho, J. M., Nancy, M. K., Maathai, R. G., & Gateri, L. M. (2008). Biochemical changes in the plasma of vervet monkeys (Chlorocebus aethiops) experimentally infected with Trypanosoma brucei rhodesiense. Journal of Cell and Animal Biology, 2(7), 150-157. | en_US |
dc.identifier.uri | http://www.academicjournals.org/article/article1380184591_Ngure%20et%20al.pdf | |
dc.identifier.uri | http://hdl.handle.net/11295/80255 | |
dc.description.abstract | Biochemical evaluation of plasma during disease conditions gives an indication of the functional status
of the various body organs. Biochemical analysis of plasma from 32 vervet monkeys (Chlorocebus
aethiops) infected with Trypanosoma brucei rhodesiense revealed at various stages of infection,
dramatic increases in blood urea nitrogen, triglycerides, cholesterol and tissue enzymes including
creatine kinase (CK), alkaline phosphatase (ALKP), alanine aminotransferase (ALT) and lactate
dehydrogenase (LDH). Serum levels of total protein however showed a decline one week after infection
but returned to control levels while creatinine increased then declined to control levels. The changes in
total proteins, enzyme levels and albumin indicate severe tissue damage, metabolic abnormality and
the development of liver and kidney malfunctions similar to those reported in sleeping sickness
patients. This demonstrates that the vervet monkey is a good model to study various aspects of the
disease. The changes in total proteins, albumin and triglycerides could also have important
implications on the pathogenesis of African trypanosomosis and the effectiveness of treatment. | en_US |
dc.language.iso | en | en_US |
dc.publisher | University of Nairobi | en_US |
dc.title | Biochemical changes in the plasma of vervet monkeys (Chlorocebus aethiops) experimentally infected with Trypanosoma brucei rhodesiense | en_US |
dc.type | Article | en_US |
dc.type.material | en_US | en_US |