| dc.contributor.author | Faraj, Omar A | |
| dc.contributor.author | Matheka, Duncan | |
| dc.contributor.author | Abdulrahman, Fatma K | |
| dc.contributor.author | Muriithi, , Anne | |
| dc.date.accessioned | 2015-04-02T06:51:50Z | |
| dc.date.available | 2015-04-02T06:51:50Z | |
| dc.date.issued | 2012 | |
| dc.identifier.citation | Alkizim, Faraj Omar, et al. "Inhibitory effect of Mangifera indica on gastrointestinal motility." Medicinal Chemistry and Drug Discovery 2.1 (2012): 9-16. | en_US |
| dc.identifier.uri | http://hdl.handle.net/11295/81888 | |
| dc.description.abstract | Diarrhoea, the second leading cause of child mortality, accounts for 1.5 million
deaths, impeding the realization of the fourth Millennium Development Goal. A
review of existing treatment modalities and formulation of newer ones is therefore
necessary. Mango fruit (Mangifera indica) kernel has been used as anti-diarrhoea
remedy. Its mechanism is however uncertain. The current study therefore aimed to
investigate the in-vitro effect of Mangifera indica kernel extract (MIE) on intestinal
motility, and elucidate its mechanism. The dose related effects of MIE was tested
on sections of jejunum freshly isolated from rabbits. Various receptors were then
selectively blocked to investigate its mechanism. Finally the effect of MIE was
compared with that of loperamide. MIE reversibly inhibited motility by -46.38 ±
5.83 % (p<0.001), via a sympathomimetic mechanism. Its efficacy was comparable
to loperamide, making it a potential antidiarrheal agent. | en_US |
| dc.language.iso | en | en_US |
| dc.publisher | University of Nairobi | en_US |
| dc.subject | Diarrhoea; mango kernel; gut motility; Mangifera indica | en_US |
| dc.title | Inhibitory effect of Mangifera indica on gastrointestinal motility | en_US |
| dc.type | Article | en_US |
| dc.type.material | en_US | en_US |
