| dc.description.abstract | Tephrosia species are widely used
in East African traditional medicinal
practice to treat various infectious
diseases. In our continued search
for antiplasmodial agents from
Tephrosia species found in Kenya a
new flavone [(+)-Tephrodin] from
the stem of T. purpurea was
isolated.1
Its 1H NMR spectrum is identical
with the spectrum reported for
tephrodin which was isolated from
T. polystachyoides.2
1 Muiva-Mutisya L., Macharia B., Heydenreich M., Koch A., Akala H.M., Derese S., Omosa L.K., Yusuf A.O., Kamau E., Yenesew, A. Phytochem. Lett., in press.
2 Vleggar R., Smalberger T.M., de Waal H.L. Tetrahedron Lett. 13 (1972) 703
However, in contrast to the
levorotatory tephrodin found by Vleggar
et al. our compound showed
dextrorotatory behaviour ([α]D20 = +4.7°).
This suggests that both compounds must
be stereoisomers.
To clarify the relative configuration of
our compound experimental data are
compared with theoretical quantum
chemical calculations (DFT B3LYP 6311G**).
For configurational and conformational
analysis the coupling constants between
H-3“ and both protons H-2“ (2.3 and 1.0
Hz, resp.) can be used: | en_US |
