The fate of the strain of mycoplasma mycoides var. mycoides following vaccination of cattle

Abstract

Mycoplasma mycoides var. mycoides (M. mycoides) was recovered from lymph nodes draining the tail region of cattle vaccinated with the T1 strain of M. mycoides for up to 71 days. M. mycoides antigens were not detected until 3 days after vaccination using the agar gel diffusion test. They were wide spread in the animal tissues by the 11th day and were detected up to 204 days. The earliest time at which complement fixing (C.F.) and agglutinating antibodies were detected was 5 days. Both CF and agglutinating antibodies persisted up to 30 days following vaccination. It is suggested that viable organisms stimulate immunity against contagious bovine pleuropneumonia and the associated antigens maintain the immunity.