In vivo anti-diabetic effects of aqueous leaf extracts of Rhoicissus tridentata in alloxan induced diabetic mice
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Date
2015Author
Mukundi, Mwangi J
Mwaniki, Njagi E N
Ngugi, M Piero
Njagi, J Murugi
Agyirifo, S Daniel
Gathumbi, K Pete
Muchugi, N Alice
Language
enMetadata
Show full item recordAbstract
The drawbacks associated with conventional anti-diabetic agents have largely stimulated desire for alternative and
complementary anti-diabetic agents, majority of which are plant-derived. The medicinal plant,
Rhoicissus tridentata
has
been used extensively in traditional medical practice against various ailments. However, its ethno medicinal use against
diabetes mellitus has not been scientifically evaluated and validated. This study was, therefore, designed to evaluate
the anti-diabetic potential of aqueous leaf extracts of
Rhoicissus tridentata
in alloxan induced diabetic mice. As the
results show, the aqueous leaf extracts of
Rhoicissus tridentata
showed anti-diabetic activity. The intraperitoneal route
of herbal extract administration was found to be more effective than the oral route. Further, qualitative and quantitative
phytochemical screening of aqueous leaf extracts of
Rhoicissus tridentata
indicated the presence of phenols, alkaloids,
flavonoids, tannins and saponins. However, cardiac glycosides and phylobatanins were not detected.
URI
http://www.omicsgroup.org/journals/in-vivo-antidiabetic-effects-of-aqueous-leaf-extracts-of-rhoicissus-tridentatain-alloxan-induced-diabetic-mice-2329-6631-1000131.pdfhttp://hdl.handle.net/11295/92225
Citation
Mukundi MJ , Mwaniki NEN , Piero NM , Murugi NJ , Daniel AS , et al. (2015) In Vivo Anti-diabetic Effects of Aqueous Leaf Extracts of Rhoicissus tridentata in Alloxan Induced Diabetic Mice. J Develop Drugs 4: 131Publisher
University of Nairobi