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dc.contributor.authorGuppy, M.
dc.contributor.authorBallantyne, J.
dc.date.accessioned2015-11-04T07:52:05Z
dc.date.available2015-11-04T07:52:05Z
dc.date.issued1981
dc.identifier.citationGuppy, M., and J. Ballantyne. "The importance of water and oxygen in the evolution of hydrogen shuttle mechanisms." Comparative Biochemistry and Physiology Part B: Comparative Biochemistry 69.1 (1981): 1-4.en_US
dc.identifier.urihttp://www.sciencedirect.com/science/article/pii/0305049181902005
dc.identifier.urihttp://hdl.handle.net/11295/92246
dc.description.abstract1. 1. Aerobic carbohydrate metabolism necessitates a hydrogen shuttle mechanism. 2. 2. This mechanism must supply glyceraldehyde 3-phosphate dehydrogenase with NAD and must not, in itself, detract from the long-term nature of the aerobic metabolic process. 3. 3. There are four known shuttle mechanisms; all are relatively complex, involving reducing equivalents crossing the mitochondrial membrane. 4. 4. However, at least two completely cytoplasmic mechanisms can be theoretically designed which would adequately supply NAD for glyceraldehyde 3-phosphate dehydrogenase. 5. 5. It is concluded that the mechanisms involving the mitochondria were selected as only these, by incorporating cytochrome oxidase as the terminal reaction of the shuttle, ensure that neither the hydrogen acceptor, nor the reduced end-product, are ever limiting.en_US
dc.language.isoenen_US
dc.publisherUniversity of Nairobien_US
dc.titleThe importance of water and oxygen in the evolution of hydrogen shuttle mechanismsen_US
dc.typeArticleen_US
dc.type.materialenen_US


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