Experimental evaluation of inactivated and live attenuated vaccines against Mycoplasma mycoides subsp. mycoides
Date
2016Author
Mwirigi, Martin
Nkando, Isabel
Aye, Racheal
Soi, Reuben
Ochanda, Horace
Berberove, Emil
Pottere, Andrew
Gerdtse, Volker
Perez-Casale, Jose
Naessensa, Jan
Wesonga, Hezron
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
The current control method for contagious bovine pleuropneumonia (CBPP) in Africa is vaccination with a live, attenuated strain of Mycoplasma mycoides subsp. mycoides (Mmm). However, this method is not very efficient and often causes serious adverse reactions. Several studies have attempted to induce protection using inactivated mycoplasma, but with widely contradictory results. Therefore, we compared the protective capacity of the live T1/44 vaccine with two inactivated preparations of Mmm strain Afadé, inoculated with an adjuvant. Protection was measured after a challenge with Afadé. The protection levels were 31%, 80.8% and 74.1% for the formalin-inactivated, heat-inactivated and live attenuated preparations, respectively. These findings indicate that low doses of heat-inactivated Mmm can offer protection to a level similar to the current live attenuated (T1/44) vaccine formulation.
URI
http://www.sciencedirect.com/science/article/pii/S0165242715300295http://hdl.handle.net/11295/96044
Citation
Veterinary Immunology and Immunopathology Volume 169, January 2016, Pages 63–67Rights
Attribution-NonCommercial-NoDerivs 3.0 United StatesUsage Rights
http://creativecommons.org/licenses/by-nc-nd/3.0/us/Collections
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