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Pterocarpans and isoflavones from the root bark of millettia micans and of millettia dura

dc.contributor.authorMarco, M
dc.contributor.authorDeyou, T
dc.contributor.authorGruhonjic, A
dc.contributor.authorHolleran, JP
dc.contributor.authorDuffy, S
dc.contributor.authorHeydenreich, M
dc.contributor.authorFitzpatric, PA
dc.contributor.authorLandberg, G
dc.contributor.authorKoch, A
dc.contributor.authorDerese, S
dc.contributor.authorPelletier, J
dc.contributor.authorAvery, VM
dc.contributor.authorErdélyi, Máté
dc.contributor.authorYenesew, A
dc.date.accessioned2016-12-09T09:37:42Z
dc.date.available2016-12-09T09:37:42Z
dc.date.issued2016
dc.identifier.citationMarco M, Deyou T, Gruhonjic A, Holleran JP, Duffy S, Heydenreich M, Fitzpatric PA, Landberg G, Koch A, Derese S, Pelletier J, Avery VM, Erdélyi Máté, Yenesew A. "Pterocarpans and Isoflavones from the Root Bark of Millettia micans and of Millettia dura." Advances in Drug Discovery and Development. 2016: 1-8.en_US
dc.identifier.urihttps://profiles.uonbi.ac.ke/sderese/publications/pterocarpans-and-isoflavones-root-bark-millettia-micans-and-millettia-dura
dc.identifier.urihttp://hdl.handle.net/11295/97953
dc.description.abstractFrom the CH2Cl2/CH3OH (1:1) extract of the root bark of Millettia micans, a new pterocarpan, (6aR,11aR)-7,8,9-trimethoxy-3-hydroxypterocarpan (1), named micanspterocarpan, was isolated. Similar investigation of the CH2Cl2/CH3OH (1:1) extract of the root bark of Millettia dura gave a further new pterocarpan, 3-O-prenylmaackiain (2) along with six known isoflavones (3-8) and a chalcone (9). All purified compounds were identified by NMR and MS, and the absolute configuration of 1 was established by quantum chemical CD calculation. The isolated constituents, calopogonium isoflavone B (3) and isoerythrin A-4'- (3-methylbut-2-enyl) ether (4) showed marginal activities against the 3D7 and the Dd2 strains of Plasmodium falciparum (70-90% inhibition at 40en_US
dc.language.isoenen_US
dc.publisherUniversity of Nairobien_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.titlePterocarpans and isoflavones from the root bark of millettia micans and of millettia duraen_US


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