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dc.contributor.authorOwuor, B.O.
dc.contributor.authorOchanda J O.
dc.contributor.authorKokwaro, J.O.
dc.contributor.authorCheruiyot, A.C.
dc.contributor.authorYeda, R.A
dc.contributor.authorOkudo, C.A.
dc.contributor.authorAkala, H.M.
dc.description.abstractEthnopharmacological relevance: Drug resist ance in malaria is a recur ring subj ect that th reaten s publi c health glob ally. There is an urgent nee d to seek new antima larial ag ents. This stud y seeking new antima larials from medic inal plan ts is guided by et hnobota ny. Materials and methods: Medicina l plants of the Luo and K uria ethnic groups of Kenya with high usa ge report s were screened in vitr o for th eir antiplas modial activity using th e SYB R Green I fluor escence assa y (MSF assa y). Results: The IC50 ’s for drugs and total pl ant extr acts ra nged from 0.012 17 to 10.679 m g/ml. Ex tracts were more activ e on chloroqui ne s ensitive than re sistant Plasm odium falci parum strains. Tylosema fassoglense, Ageratum conyzoides and Ocimum kilimandscharicum exh ibited promisin g results. Plectranthus barbatus did not show activ ity. Conclusion: Eth nobotan ical knowle dge wa s sufficie ntly reliab le for identif ying plant extr acts with antipla smodial act ivity.en
dc.subjectIn vitro antipasmodial acivityen
dc.subjectLuo medicinal plantsen
dc.subjectKuria medicinal plantsen
dc.titleIn vitro antiplasmodial activity of selected Luo and Kuria medicinal plantsen
local.publisherCentre for Biotechnology and Bioinformaticsen

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