University of Nairobi Institutional Repository: Recent submissions
Now showing items 1-20 of 87679
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Perceptions and Acceptability of Donating and Use of Donated Human Milk and Human Milk Banking in Nairobi, Kenya
(Wiley, 2019-05-16)Donor Human Milk (DHM) is recomended as the best alternative when use of mothers' own milk is not a feasible option. Kenya has not yet established Human Milk Banks (HMBs) for provision of safe DHM, which is free from any ... -
Multi-locus genotyping reveals absence of genetic structure in field populations of the brown ear tick (Rhipicephalus appendiculatus) in Kenya.
(2016-02-07)Rhipicephalus appendiculatus is an important tick vector of several pathogens and parasitizes domestic and wild animals across eastern and southern Africa. However, its inherent genetic variation and population structure ... -
Analyses of mitochondrial genes reveal two sympatric but genetically divergent lineages of Rhipicephalus appendiculatus in Kenya
(BMC, 2016-06-22)The ixodid tick Rhipicephalus appendiculatus transmits the apicomplexan protozoan parasite Theileria parva, which causes East coast fever (ECF), the most economically important cattle disease in eastern and southern Africa. ... -
Expressed Centromere Specific Histone 3 (CENH3) Variants in Cultivated Triploid and Wild Diploid Bananas (Musa spp.).
(2017-06-29)Centromeres are specified by a centromere specific histone 3 (CENH3) protein, which exists in a complex environment, interacting with conserved proteins and rapidly evolving satellite DNA sequences. The interactions may ... -
Alkaliphilic Enzymes and Their Application in Novel Leather Processing Technology for Next-Generation Tanneries.
(Springer, 2019-05-03)Leather manufacturing involves conversion of raw skin and hides into leather (stable material) through series of mechanical and chemical operations. The leather industry has attracted public outcry due to severe environmental ... -
Antimalarial Pyrido[1,2-a]benzimidazoles: Lead Optimization, Parasite Life Cycle Stage Profile, Mechanistic Evaluation, Killing Kinetics, and in Vivo Oral Efficacy in a Mouse Model
(ASC, 2017-02-23)Further structure-activity relationship (SAR) studies on the recently identified pyrido[1,2-a]benzimidazole (PBI) antimalarials have led to the identification of potent, metabolically stable compounds with improved in vivo ... -
Treatment Outcomes and Associated Factors among Hospitalized Stroke Patients at Shashemene Referral Hospital, Ethiopia.
(2016-09-09)The 2013 Global Burden of Disease report indicated that 80% of stroke deaths occur in low- and middle-income regions. Although stroke has been consistently reported as one of the three leading causes of morbidity and ... -
Few Plasmodium falciparum merozoite ligand and erythrocyte receptor pairs show evidence of balancing selection
(Elsevier, 2019-04)Erythrocyte surface proteins have been identified as receptors of Plasmodium falciparum merozoite proteins. The ligand-receptor interactions enable the parasite to invade human erythrocytes, initiating the clinical symptoms ... -
Whole genome characterization of human influenza A(H1N1)pdm09 viruses isolated from Kenya during the 2009 pandemic.
(Elsevier, 2016-06)An influenza pandemic caused by a novel influenza virus A(H1N1)pdm09 spread worldwide in 2009 and is estimated to have caused between 151,700 and 575,400 deaths globally. While whole genome data on new virus enables a ... -
Genetically Determined Response to Artemisinin Treatment in Western Kenyan Plasmodium falciparum Parasites.
(PLoS, 2016-09-09)Genetically determined artemisinin resistance in Plasmodium falciparum has been described in Southeast Asia. The relevance of recently described Kelch 13-propeller mutations for artemisinin resistance in Sub-Saharan Africa ... -
Unclear association between levels of Plasmodium falciparum lactate dehydrogenase (PfLDH) in saliva of malaria patients and blood parasitaemia: diagnostic implications?
(BMC, 2018-01-05)The use of saliva in diagnosis of infectious diseases is an attractive alternative to procedures that involve blood drawing. It promises to reduce risks associated with accidental needle pricks and improve patient compliance ... -
gyrA and parC mutations in fluoroquinolone-resistant Neisseria gonorrhoeae isolates from Kenya.
(BMC, 2019-04-08)Phenotypic fluoroquinolone resistance was first reported in Western Kenya in 2009 and later in Coastal Kenya and Nairobi. Until recently gonococcal fluoroquinolone resistance mechanisms in Kenya had not been elucidated. ... -
Perioperative patient outcomes in the African Surgical Outcomes Study: a 7-day prospective observational cohort study.
(Elsevier, 2018-04-21)BACKGROUND: There is a need to increase access to surgical treatments in African countries, but perioperative complications represent a major global health-care burden. There are few studies describing surgical outcomes ... -
Maternal and neonatal outcomes after caesarean delivery in the African Surgical Outcomes Study: a 7-day prospective observational cohort study.
(Elsevier, 2019-04-07)BACKGROUND: Maternal and neonatal mortality is high in Africa, but few large, prospective studies have been done to investigate the risk factors associated with these poor maternal and neonatal outcomes. METHODS: A ... -
Assisted partner notification services to augment HIV testing and linkage to care in Kenya: study protocol for a cluster randomized trial.
(BMC, 2015)BACKGROUND: HIV case-finding and linkage to care are critical for control of HIV transmission. In Kenya, >50% of seropositive individuals are unaware of their status. Assisted partner notification is a public health ... -
Knowledge of Nairobi East District Community Health Workers concerning HIV-related orofacial lesions and other common oral lesions.
(BMC, 2014)BACKGROUND: Human immunodeficiency virus (HIV) related orofacial lesions (HROLs) impact negatively on the health of patients and could be managed at primary healthcare (PHC) level. Community health workers (CHWs) are ... -
The Pattern of Orbital Fractures Managed at Two Referral Centers in Nairobi, Kenya.
(Wolters Kluwer, 2017)Orbital fractures are one of the commonest injuries in mid-face trauma and can lead to significant functional and cosmetic defects. This study was aimed at analyzing the pattern of orbital fractures at 2 referral centers ... -
Prosthodontic Rehabilitation of a Child with Ectodermal Dysplasia: A Preliminary Report.
(2019)This case history report describes the dental management of a child with ectodermal dysplasia with the premise that appropriate and early dental management positively impacts the oral health-related quality of life of such ... -
Time to presentation and diagnosis of esophageal cancer in patients seen at the Kenyatta National Hospital
(KMA, 2018)Background: Esophageal Cancer (EC) is one of the leading causes of cancer death in Kenya. Majority of the patients with esophageal cancer at Kenyatta National Hospital (KNH) present at an advanced stage limiting their ...
