New ent-clerodane and abietane diterpenoids from the roots of Kenyan croton megalocarpoides Friis & M. G. Gilbert
Date
2016Author
Ndunda, Beth
Langat, Moses K.
Mulholland, Dulcie A.
Eastman, Harry
Jacob, Melissa R.
Khan, Shabana I.
Walker, Larry A.
Muhammad, Ilias
Kerubo, Leonidah O.
Midiwo, Jacob O.
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
The roots of the endangered medicinal plant Croton megalocarpoides collected in Kenya were investigated and twenty-two compounds isolated. Among them were twelve new ent-clerodane (1–12) and a new abietane (13) diterpenoids, alongside the known crotocorylifuran (4 a), two known abietane and four known ent-trachylobane diterpenoids, and the triterpenoids, lupeol and acetyl aleurotolic acid. The structures of the compounds were determined using NMR, HRMS and ECD. The isolated compounds were evaluated against a series of microorganisms (fungal and bacteria) and also against Plasmodium falciparum, however no activity was observed.
#
Key words
Croton megalocarpoides - Euphorbiaceae - abietane - ent-clerodane - ent-trachylobane - diterpenoids - electronic circular dichroism
URI
https://www.thieme-connect.com/products/ejournals/html/10.1055/s-0042-108857http://hdl.handle.net/11295/100737
Citation
Ndunda, Beth, et al. "New ent-Clerodane and Abietane Diterpenoids from the Roots of Kenyan Croton megalocarpoides Friis & MG Gilbert." Planta medica 82.11/12 (2016): 1079-1086.Publisher
University of Nairobi
Rights
Attribution-NonCommercial-NoDerivs 3.0 United StatesUsage Rights
http://creativecommons.org/licenses/by-nc-nd/3.0/us/Collections
The following license files are associated with this item: