dc.contributor.author | Ndunda, Beth | |
dc.contributor.author | Langat, Moses K. | |
dc.contributor.author | Mulholland, Dulcie A. | |
dc.contributor.author | Eastman, Harry | |
dc.contributor.author | Jacob, Melissa R. | |
dc.contributor.author | Khan, Shabana I. | |
dc.contributor.author | Walker, Larry A. | |
dc.contributor.author | Muhammad, Ilias | |
dc.contributor.author | Kerubo, Leonidah O. | |
dc.contributor.author | Midiwo, Jacob O. | |
dc.date.accessioned | 2017-03-28T07:30:03Z | |
dc.date.available | 2017-03-28T07:30:03Z | |
dc.date.issued | 2016 | |
dc.identifier.citation | Ndunda, Beth, et al. "New ent-Clerodane and Abietane Diterpenoids from the Roots of Kenyan Croton megalocarpoides Friis & MG Gilbert." Planta medica 82.11/12 (2016): 1079-1086. | en_US |
dc.identifier.uri | https://www.thieme-connect.com/products/ejournals/html/10.1055/s-0042-108857 | |
dc.identifier.uri | http://hdl.handle.net/11295/100737 | |
dc.description.abstract | The roots of the endangered medicinal plant Croton megalocarpoides collected in Kenya were investigated and twenty-two compounds isolated. Among them were twelve new ent-clerodane (1–12) and a new abietane (13) diterpenoids, alongside the known crotocorylifuran (4 a), two known abietane and four known ent-trachylobane diterpenoids, and the triterpenoids, lupeol and acetyl aleurotolic acid. The structures of the compounds were determined using NMR, HRMS and ECD. The isolated compounds were evaluated against a series of microorganisms (fungal and bacteria) and also against Plasmodium falciparum, however no activity was observed.
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Key words
Croton megalocarpoides - Euphorbiaceae - abietane - ent-clerodane - ent-trachylobane - diterpenoids - electronic circular dichroism | en_US |
dc.language.iso | en | en_US |
dc.publisher | University of Nairobi | en_US |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 United States | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/us/ | * |
dc.subject | Croton megalocarpoides - Euphorbiaceae - abietane - ent-clerodane - ent-trachylobane - diterpenoids - electronic circular dichroism | en_US |
dc.title | New ent-clerodane and abietane diterpenoids from the roots of Kenyan croton megalocarpoides Friis & M. G. Gilbert | en_US |
dc.type | Article | en_US |