HIV-Exposed seronegative commercial sex workers show a quiescent phenotype in the CD4+ T cell compartment and reduced expression of HIV-dependent host factors
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Date
2010Author
McLaren, Paul J
Ball, T. Blake
Wachihi, Charles
Jaoko Walter G.
Kelvin, David J
Danesh, Ali
Kimani, Joshua
Plummer, Francis A.
Fowke, Keith R.
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
Studies of human immunodeficiency virus (HIV)–exposed seronegative individuals are crucial to informvaccine
design. In the present study we demonstrated that HIV-exposed seronegative commercial sex workers produce
lower levels of proinflammatory cytokines at baseline than HIV-negative control subjects. We also showed
that CD4+ T cells of HIV-exposed seronegative commercial sex workers have a characteristically lower level
of gene expression that can be seen in differentially expressed genes and systems crucial for HIV replication,
such as the T cell receptor pathway and previously identified HIV dependency factors. This apparent lowered
activation results in a phenomenon we term “immune quiescence,” which may contribute to host resistance
to HIV.
URI
http://www.ncbi.nlm.nih.gov/pubmed/20887221http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/10094
Citation
The Journal of Infectious Diseases 2010Collections
- Faculty of Health Sciences (FHS) [10377]