Faculty of Health Sciences (FHS)
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Recent Submissions
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Chewable Antacid Tablets: Are Disintegration Tests Relevant?
(University of Nairobi, 2020)A recently published FDA guidance on chewable tablets has addressed the quality attributes of this class of dosage forms. This study evaluated disintegration as a quality attribute for a number of commercially available ... -
Molecular evidence confirms occurrence of Rhipicephalus microplus Clade A in Kenya and sub-Saharan Africa.
(University of Nairobi, 2020)Background The tick vector Rhipicephalus microplus which transmits Babesia spp. and rickettsial pathogens has not been reported in Kenya since 1998. More recently, the pathogenic Babesia bovis has been detected in cattle ... -
Employing learning health system principles to advance research on severe neonatal and pediatric illness in Kenya.
(BMJ, 2021)We have worked to develop a Clinical Information Network (CIN) in Kenya as an early form of learning health systems (LHS) focused on paediatric and neonatal care that now spans 22 hospitals. CIN's aim was to examine important ... -
New WHO guidelines on pediatric mortality and morbidity auditing.
(University of Nairobi, 2019)No abstract available. -
Prediction modelling of inpatient neonatal mortality in high-mortality settings.
(BMJ, 2020)Objective: Prognostic models aid clinical decision making and evaluation of hospital performance. Existing neonatal prognostic models typically use physiological measures that are often not available, such as pulse oximetry ... -
Factors influencing breast cancer screening practices among women of reproductive age in South Kayonza District,Rwanda
(University of Nairobi, 2021-07)Introduction: Breast cancer in Rwanda is a major concern for women's health, as most breast cancer diagnoses are made at an advanced stage. Yet, diagnosis can be done early with breast cancer screening practices. Aim: ... -
Isolated duodenal perforation at D4 following blunt abdominal trauma.
(Elsevier Ltd, 2020)Introduction: Isolated duodenal injuries are particularly rare in blunt abdominal trauma as the duodenum is at a deep and relatively well-protected anatomical site. Case presentation: We present a case report of a ... -
Local/regional flaps for extensive abdominal wall defects: Case series.
(University of Nairobi, 2020)INTRODUCTION Extensive abdominal wall defects requiring reconstruction with flaps are best done with free flaps. However, free flaps are not readily available in many countries. Free flaps are associated with long ... -
Dementia in Africa: Current evidence, knowledge gaps, and future directions.
(University of Nairobi, 2021)In tandem with the ever-increasing aging population in low and middle-income countries, the burden of dementia is rising on the African continent. Dementia prevalence varies from 2.3% to 20.0% and incidence rates are 13.3 ... -
Perceptions and experiences of dementia and its care in rural Kenya.
(University of Nairobi, 2021)Objectives: We aimed to explore the perceptions towards dementia and related care across three stakeholder groups in rural Kenya. Methods: A total of 38 key stakeholders (carers of persons with dementia, health care ... -
Psychotic-like experiences among 9,564 Kenyan adolescents and young adults.
(Elsevier B.V., 2021)Objective: To investigate the prevalence and characteristics of psychotic-like experiences (PLE) in a large cohort of Kenyan adolescents and young adults. Method: The Washington Early Recognition Center Affectivity and ... -
Factors associated with the onset of major depressive disorder in adults with type 2 diabetes living in 12 different countries: results from the INTERPRET-DD prospective study.
(University of Nairobi, 2020)Aims: To examine the factors that are associated with changes in depression in people with type 2 diabetes living in 12 different countries. Methods: People with type 2 diabetes treated in out-patient settings aged 18-65 ... -
A randomized clinical trial of mobile phone motivational interviewing for alcohol use problems in Kenya.
(University of Nairobi, 2020)Aim: To test the effectiveness of a motivational interviewing (MI) intervention using the mobile phone among adults with alcohol use problems. Design: A randomized clinical trial of mobile MI and standard in-person MI ... -
Where is the global in global mental health? A call for inclusive multicultural collaboration.
(University of Nairobi, 2020)No abstract available -
Cytopenia among CML Patients on Imatinib in Kenya: Types, Grades, and Time Course.
(University of Nairobi, 2020)Background: Imatinib mesylate is the gold standard for the treatment of all phases of Philadelphia-positive chronic myeloid leukemia. Patients on imatinib treatment may develop cytopenia due to drug toxicity. This study ... -
Stakeholder-engaged research: strategies for the prevention and control of overweight and obesity in Kenya
(University of Nairobi, 2021)Background: This study was done as part of a larger study that aims to identify the most impactful and cost-effective strategies for the prevention and control of overweight and obesity in Kenya. Our objective was to involve ... -
Neurocognition in Kenyan youth at clinical high risk for psychosis
(University of Nairobi, 2021)Introduction: Cognitive deficits are typically seen in schizophrenia and in the prodrome, and are a major predictor of functional outcomes in patients. In Africa, few studies have investigated neurocognition in psychosis, ... -
Urine Biomarker Assessment of Infant Adherence to Isoniazid Prophylaxis
(University of Nairobi, 2021)We assessed adherence in an infant tuberculosis prevention trial in Kenya with a urine isoniazid metabolite-detecting dipstick. Ninety-seven infants had 155 assays performed; 77 (49.7%) were found to be positive despite ... -
Cerebral Small Vessel Disease in Sporadic and Familial Alzheimer Disease
(University of Nairobi, 2021)Alzheimer disease (AD) is the most common cause of dementia. Biological definitions of AD are limited to the cerebral burden of amyloid β plaques, neurofibrillary pathology, and neurodegeneration. However, current evidence ... -
Cytotoxicity of isoflavones from Millettia dura
(University of Nairobi, 2021-08)The first phytochemical investigation of the flowers of Millettia dura resulted in the isolation of seven isoflavones, a flavonol and a chalcone. Eleven isoflavones and a flavonol isolated from various plant parts from ...
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