Faculty of Health Sciences (FHS)

Assessing the accuracy of presumptive distal femoral cuts in the conduct of conventional total knee replacement in Kenyan patients with end stage osteoarthritis of the knee

Murerwa, M.; Mulimba, J. A. O.; Gakuya, E. M. (East African Orthopaedic Journal, 2021-10-18)

Background: Total Knee Replacements in our setting are performed using conventional techniques. This involves use of an intramedullary rod and jig to perform the Distal Femoral Cut (DFC). Ideally the magnitude of the ...

Factors impacting on diabetes knowledge, medication adherence and glycemic control among adult diabetics visiting a county teaching and referral hospital in Kenya: a cross-sectional study.

Nyamu, David G; Tirop, Lucy Jemutai; Mwangasha, Faith Machocho (University of Nairobi, 2021)

Introduction: optimal management of diabetes involves interplay between patients' understanding of their disease and medication adherence, which would eventually influence glycemic control. However, there is scant published ...

Examination of WHO/INRUD Core Drug Use Indicators at Public Primary Healthcare Centers in Kisii County, Kenya.

Okalebo, Faith A; Guantai, Eric M; Nyabuti, Aggrey O (University of Nairobi, 2020)

Background: Irrational drug use is a global problem. However, the extent of the problem is higher in low-income countries. This study sets out to assess and characterize drug use at the public primary healthcare centers ...

Iron as the concert master in the pathogenic orchestra playing in sporadic Parkinson's disease

Riederer, P; Monoranu, C; Strobel, S; Iordache, T; Sian-Hülsmann, J (University of Nairobi, 2021-10)

About 60 years ago, the discovery of a deficiency of dopamine in the nigro-striatal system led to a variety of symptomatic therapeutic strategies to supplement dopamine and to substantially improve the quality of life of ...

Depression and its associated factors: perceived stress, social support, substance use and related sociodemographic risk factors in medical school residents in Nairobi, Kenya

Shah, Sayed Shah N H; Laving, Ahmed; Okech-Helu, Violet C; Manasi, Kumar (University of Nairobi, 2021-09)

Background: Little data exists regarding depression and its associated factors in medical residents and doctors in Sub-Saharan Africa. Residents are at high risk of developing depression owing to the stressful nature of ...

Chewable Antacid Tablets: Are Disintegration Tests Relevant?

Nyamweya, Nasser N; Kimani, Samantha N; Abuga, Kennedy O (University of Nairobi, 2020)

A recently published FDA guidance on chewable tablets has addressed the quality attributes of this class of dosage forms. This study evaluated disintegration as a quality attribute for a number of commercially available ...

Molecular evidence confirms occurrence of Rhipicephalus microplus Clade A in Kenya and sub-Saharan Africa.

Nguu, Edward K; Kanduma, Esther G; Emery, David; Githaka, Naftaly W; Bishop, Richard P; Šlapeta, Jan (University of Nairobi, 2020)

Background The tick vector Rhipicephalus microplus which transmits Babesia spp. and rickettsial pathogens has not been reported in Kenya since 1998. More recently, the pathogenic Babesia bovis has been detected in cattle ...

Employing learning health system principles to advance research on severe neonatal and pediatric illness in Kenya.

Irimu, Grace; Aluvaala, Jalemba; English, Mike; Akech, Samuel; Ogero, Morris; Isaaka, Lynda; Malla, Lucas; Tuti, Timothy; Gathara, David; Oliwa, Jacquie; Agweyu, Ambrose (BMJ, 2021)

We have worked to develop a Clinical Information Network (CIN) in Kenya as an early form of learning health systems (LHS) focused on paediatric and neonatal care that now spans 22 hospitals. CIN's aim was to examine important ...

New WHO guidelines on pediatric mortality and morbidity auditing.

Irimu, Grace; Duke, Trevor; Were, Wilson (University of Nairobi, 2019)

No abstract available.

Prediction modelling of inpatient neonatal mortality in high-mortality settings.

Aluvaala, Jalemba; Collins, Gary; Maina, Beth; Mutinda, Catherine; Waiyego, Mary; Berkley, James A; English, Mike (BMJ, 2020)

Objective: Prognostic models aid clinical decision making and evaluation of hospital performance. Existing neonatal prognostic models typically use physiological measures that are often not available, such as pulse oximetry ...

Factors influencing breast cancer screening practices among women of reproductive age in South Kayonza District,Rwanda

Igiraneza, Pierre C; Omondi, Lilian A; Nikuze, Bellancille; Uwayezu, Marie G; Fitch, Margaret; Niyonsenga, Gaudence (University of Nairobi, 2021-07)

Introduction: Breast cancer in Rwanda is a major concern for women's health, as most breast cancer diagnoses are made at an advanced stage. Yet, diagnosis can be done early with breast cancer screening practices. Aim: ...

Isolated duodenal perforation at D4 following blunt abdominal trauma.

Kiptoon, Dan; Mutua, Irene; Omondi, Marilynn (Elsevier Ltd, 2020)

Introduction: Isolated duodenal injuries are particularly rare in blunt abdominal trauma as the duodenum is at a deep and relatively well-protected anatomical site. Case presentation: We present a case report of a ...

Local/regional flaps for extensive abdominal wall defects: Case series.

Kiptoon, Dan; Nangole, Ferdinand W (University of Nairobi, 2020)

INTRODUCTION Extensive abdominal wall defects requiring reconstruction with flaps are best done with free flaps. However, free flaps are not readily available in many countries. Free flaps are associated with long ...

Dementia in Africa: Current evidence, knowledge gaps, and future directions.

Ndetei, David; Akinyemi, Rufus O; Yaria, Joseph; Ojagbemi, Akin; Guerchet, Maëlenn; Okubadejo, Njideka; Njamnshi, Alfred K; Sarfo, Fred S; Akpalu, Albert; Ogbole, Godwin; Ayantayo, Temitayo; et al (University of Nairobi, 2021)

In tandem with the ever-increasing aging population in low and middle-income countries, the burden of dementia is rising on the African continent. Dementia prevalence varies from 2.3% to 20.0% and incidence rates are 13.3 ...

Perceptions and experiences of dementia and its care in rural Kenya.

Ndetei, David M; Musyimi, Christine W; Evans-Lacko, Sara; Oliveira, Déborah; Mutunga, Elizabeth; Farina, Nicolas (University of Nairobi, 2021)

Objectives: We aimed to explore the perceptions towards dementia and related care across three stakeholder groups in rural Kenya. Methods: A total of 38 key stakeholders (carers of persons with dementia, health care ...

Psychotic-like experiences among 9,564 Kenyan adolescents and young adults.

Ndetei, David M; Mutiso, Victoria N; Mamah, Daniel (Elsevier B.V., 2021)

Objective: To investigate the prevalence and characteristics of psychotic-like experiences (PLE) in a large cohort of Kenyan adolescents and young adults. Method: The Washington Early Recognition Center Affectivity and ...

Factors associated with the onset of major depressive disorder in adults with type 2 diabetes living in 12 different countries: results from the INTERPRET-DD prospective study.

Ndetei, DM; Lloyd, C E; Sartorius, N; Ahmed, H U; Alvarez, A; Bahendeka, S; Bobrov, A E; Burti, L; Chaturvedi, S K; et al (University of Nairobi, 2020)

Aims: To examine the factors that are associated with changes in depression in people with type 2 diabetes living in 12 different countries. Methods: People with type 2 diabetes treated in out-patient settings aged 18-65 ...