A stability-indicating HPLC method for the separation of clarithromycin and related substances in bulk samples

dc.contributor.author	Abuga, Kennedy O.
dc.contributor.author	Chepkwony, Hezekiah K.
dc.contributor.author	Roets, Eugene
dc.contributor.author	Hoogmartens, Jos
dc.date.accessioned	2013-02-18T13:33:13Z
dc.date.issued	2001-11
dc.identifier.citation	J. Sep. Science, 24: 849–855.	en
dc.identifier.uri	http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/10125
dc.description.abstract	Clarithromycin is a 6-O-methylated semi-synthetic derivative of erythromycin A, which is more resistant towards acid decomposition. Commercial clarithromycin samples contain several potential impurities arising from the manufacturing process and degradation. A simple, selective, and sensitive isocratic liquid chromatographic method has been developed for the impurity profiling of clarithromycin bulk samples. The method employs a XTerra RP18, 5 μm, 250×4.6 mm column thermostated at 56°C. The mobile phase consists of acetonitrile – 0.2 M potassium phosphate buffer pH 6.80 – water (40 : 3.5 : 56.5). Several peaks are of unknown identity. The method is stability indicating.	en
dc.language.iso	en	en
dc.subject	Liquid chromatography	en
dc.subject	Clarithromycin	en
dc.subject	XTerra RP18	en
dc.title	A stability-indicating HPLC method for the separation of clarithromycin and related substances in bulk samples	en
dc.type	Article	en
local.embargo.terms	6 months	en
local.embargo.lift	2013-08-17T13:33:13Z