dc.contributor.author | Okaru, AO | |
dc.contributor.author | Brunner, TS | |
dc.contributor.author | Ackermann, SM | |
dc.contributor.author | Kuballa, T | |
dc.contributor.author | Walch, SG | |
dc.date.accessioned | 2017-12-06T10:36:52Z | |
dc.date.available | 2017-12-06T10:36:52Z | |
dc.date.issued | 2017 | |
dc.identifier.citation | J Anal Methods Chem. 2017;2017:9206297. doi: 10.1155/2017/9206297. Epub 2017 Oct 18. | en_US |
dc.identifier.uri | https://www.ncbi.nlm.nih.gov/pubmed/29181224 | |
dc.identifier.uri | http://hdl.handle.net/11295/101640 | |
dc.description.abstract | A simple, rapid, and selective quantitative nuclear magnetic resonance spectroscopic method was evaluated for the determination of the content of fluorinated pharmaceuticals. 19F NMR spectra were either obtained in dimethylsulfoxide-d6 or aqueous buffer, using trifluoroacetic acid as internal standard. Quantification of 13 fluorine-containing pharmaceuticals spanning various pharmacological classes was accomplished using the proposed method. The method was found to be fit for purpose (interday precision 1.2% relative standard deviation) and may thus be applied for routine analysis and quality control of fluorine-containing pharmaceuticals due to its simplicity, nondestructive sample measurement, reliability, and high specificity. Therefore, 19F NMR may serve as a suitable analytical tool for the identification and selective determination of fluorinated pharmaceuticals used as reference materials and bulk samples. | en_US |
dc.language.iso | en | en_US |
dc.publisher | University of Nairobi | en_US |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 United States | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/us/ | * |
dc.title | Application of 19F NMR spectroscopy for content determination of fluorinated pharmaceuticals. | en_US |
dc.type | Article | en_US |