dc.contributor.author | Simonsena, Paul E. | |
dc.contributor.author | Meyrowitsch, Dan W. | |
dc.contributor.author | Jaoko, Walter | |
dc.contributor.author | Malecela, Mwele N | |
dc.contributor.author | Michael, Edwin | |
dc.date.accessioned | 2013-02-19T06:37:58Z | |
dc.date.issued | 2008 | |
dc.identifier.citation | Acta Tropica 106 (2008) 200–206 | en |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/10165 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/pubmed/18452886 | |
dc.description.abstract | The response pattern of specific antibodies to the microfilarial sheath (sheath-Ab) of the mosquito-borne
filarial parasite Wuchereria bancrofti was investigated in individuals from two East African communities
with different levels of endemicity. Individuals from both communities presented a strong inverse relationship
between positivity for sheath-Ab and being positive for microfilariae (mf) and circulating filarial
antigens (CFA). The prevalence of sheath-Ab positivity was highest in young individuals, but peaked at a
younger age in the high (1–14 years) than the low (15–19 years) endemicity community. IgG1, IgG2, IgG3
and IgE intensities to a crude adult filarial worm antigen were higher, and IgG4 intensities were lower,
in sheath-Ab positive than in sheath-Ab negative individuals, probably reflecting the infection status of
individuals. From the study it appears that individuals become sheath-Ab positive before mf and/or CFA
can be detected in the peripheral blood, and only after later disappearance of sheath-Ab from the circulation
can CFA and mf be diagnosed. In light of the findings, possible roles of the distinct sheath-Ab in
the host–parasite relationship are discussed, and a hypothesis is proposed which suggests that sheath-Ab
play an important role in the regulation of host microfilaraemia | en |
dc.language.iso | en | en |
dc.subject | Wuchereria bancrofti | en |
dc.subject | Antibodies | en |
dc.subject | Microfilarial sheath | en |
dc.subject | IFAT | en |
dc.subject | ELISA | en |
dc.subject | Circulating filarial antigens | en |
dc.subject | Tanzania | en |
dc.subject | Kenya | en |
dc.title | Immunoepidemiology of Wuchereria bancrofti infection in two East African communities: | en |
dc.title.alternative | Antibodies to the microfilarial sheath and their role in regulating host microfilaraemia | en |
dc.type | Article | en |