Toll-Like Receptor (TLR) 9 polymorphism is associated with increased Epstein-Barr virus and Cytomegalovirus acquisition in HIV-exposed infants.
Date
2017Author
Beima-Sofie, K
Wamalwa, D
Maleche-Obimbo, E
Lingappa, JR
Mackelprang, R
Gantt, S
John-Stewart, G
Casper, C
Slyker, JA.
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
Polymorphisms in the Toll-Like Receptor (TLR9) 1635 locus have been associated with HIV-1 acquisition and progression. Cytomegalovirus (CMV) and Epstein-Barr virus (EBV) acquisition were compared between Kenyan HIV-exposed infants by 1635 genotype. Having 1 or more copies of the 1635A allele was associated with increased CMV acquisition in HIV-infected infants (42% vs 11%, p = 0.03) and increased risk of EBV acquisition in HIV-exposed uninfected infants (HR = 4.2, p = 0.02) compared to 1635GG. Additionally, 1635A was associated with 0.4 log10 copies/ml lower median EBV levels in HIV-infected infants (p = 0.03). These data suggest a potentially important role for this locus in primary herpesvirus infection.
Citation
10.1097/QAD.0000000000001680. [Epub ahead of print]Publisher
University of Nairobi
Rights
Attribution-NonCommercial-NoDerivs 3.0 United StatesUsage Rights
http://creativecommons.org/licenses/by-nc-nd/3.0/us/Collections
- Faculty of Health Sciences (FHS) [10377]
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