Proconvulsant effect of khat (Catha edulis) in Sprague dawley rats
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Date
2008Author
Oyungu, Eren
Kioy, Paul G.
Patel, Nilesh B.
Type
ArticleLanguage
enMetadata
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Ethnopharmacological relevance: Catha edulis (khat) is a plant whose fresh young leaves are used by an
estimated five million people in eastern Africa and the Arabian Peninsula as a drug of recreation. The fresh
leaves and shoots are rich in cathinone, a psychostimulant with effects similar to those of amphetamines.
Psychostimulants produce a dose-related excitation of the central nervous system which can lead to
seizures and convulsions. However there are no reports on studies of the effect of this herb on brain
excitability and seizures. This knowledge is useful for doctors who may prescribe drugs whose side effects
include lowering seizure threshold because there could be additive proconvulsant effectamongkhat users.
Aim of the study: to determined whether khat lowers pentylenetetrazole (PTZ) seizure threshold.
Methodology: Male Sprague dawley rats were given fresh aqueous khat extract, old aqueous khat extract
(3 g/kg bw), methylphenidate or saline and the timed intravenous (PTZ) seizure threshold test was used
to study its effect on seizure threshold.
Results: Fresh khat (3 g/kg) and methylphenidate (4 mg/kg) lowered PTZ seizure threshold.
Conclusion: Khat lowers seizure threshold.
URI
http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/10277http://www.ncbi.nlm.nih.gov/pubmed/19056477
Citation
Journal of EthnopharmacologyCollections
- Faculty of Health Sciences (FHS) [10378]