| dc.description.abstract | The in vitro performance of metronidazole tablet product by different manufacturers avallable on the Kenyan market was evaluated. It was found that a number of generic metronidazole tablet products have quality performance equal to that of FlagylR-the Innovator product. All products confirmed to pharmacopoelal speciflcations, Three products with percent weight loss of 1.4, 11.08 and 14.93 fulled the crucial friability test, for multidose packs. Two products failed the dissolution test releasing 46.8% and 45.8% of drug In 40 minutes. Drug release from tablet was found to vary between batches for one product. Ageing appears to decrease amount of drug released from tablets but longer storage periods and more samples are required before def1nlte conclusions are drawn | en |
