Pediatric HIV Type 1 Vaccine Trial Acceptability among Mothers in Kenya
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Date
2006Author
FARQUHAR, CAREY
STEWART, GRACE C. JOHN
JOHN, FRANCIS N.
KABURA, MARJORY N.
KIARIE, JAMES N.
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
Vaccination of infants against human immunodeficiency virus type 1 (HIV-1) may prevent mother-to-child
HIV-1 transmission. Successful trials and immunization efforts will depend on the willingness of individuals
to participate in pediatric vaccine research and acceptance of infant HIV-1 vaccines. In a cross-sectional study,
pregnant women presenting to a Nairobi antenatal clinic for routine care were interviewed regarding their
attitudes toward participation in research studies and HIV-1 vaccine acceptability for their infants. Among
805 women, 782 (97%) reported they would vaccinate their infant against HIV-1 and 729 (91%) reported willingness
to enroll their infant in a research study. However, only 644 (80%) would enroll their infants if HIV1
testing was required every 3 months and 513 (64%) would agree to HIV-1 vaccine trial participation. Reasons
for not wanting to enroll in a pediatric HIV-1 vaccine trial included concerns about side effects (75%),
partner objection (34%), and fear of discrimination (10%), HIV-1 acquisition (8%), or false-positive HIV-1
results (5%). The strongest correlate of pediatric vaccine trial participation was maternal willingness to be a
vaccine trial participant herself; in univariate and multivariate models this was associated with a 17-fold increased
likelihood of participation (HR 17.1; 95% CI 11.7–25; p 0.001). We conclude from these results that
immunizing infants against HIV-1 and participation in pediatric vaccine trials are generally acceptable to
women at high risk for HIV-1 infection. It will be important to address barriers identified in this study and
to include male partners when mobilizing communities for pediatric HIV-1 vaccine trials and immunization programs.
URI
http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/10288http://www.ncbi.nlm.nih.gov/pubmed/16796522
Citation
AIDS Research and Human RetrovirusesCollections
- Faculty of Health Sciences (FHS) [10377]