|dc.contributor.author||Otieno, C . F||
|dc.identifier.citation||Oyiro P, Mwanda W, Odhiambo A, Ogutu E, Otieno CF, Abdalla F. "Serum Ferritin Levels In Patients with Sickle Cell Anaemia at the Kenyatta National Hospital." IOSR Journal of Dental and Medical Sciences (IOSR-JDMS). 2018;17(3):31-40.||en_US
The iron levels in Sickle Cell Anaemia (SCA) is thought to be increased
repeated red cell transfusion, haemolysis with subsequ
ent recycling and accumulation of iron.
transfusion is used
frequently to prevent and treat the complications of sickle cell disease. Studies have shown
that the changes in iron status that results from such therapy is associated with significant
the serum ferritin as a marker of iron levels in patients with sickle cell disease
who receive chronic red blood cell transfusion.
: The aim of this study was
the status of serum iron levels by measurement of serum ferritin in
patients with sickle cell Anaemia
at Kenyatta National Hospital.
: The study was carried out at the Kenyatta National
Materials and methods
: This study enrolled 80 patients with sickle cell anaemia.
. Samples of blood
drawn for serum ferritin, full blood count
ipheral blood film. Serum ferritin was assessed using
enzyme immunoassay sandwich method with a
final fluorescent detection (ELFA) kits.
Blood counts were done using the haematology cell counter (CELL
1300) whiles the peripheral blood films were staine
d using May Grunewald Giemsa method. Quality control
measures were observed in all tests performed by adhering to reagent manufacturers’ guidelines and standard
specimen handling/laboratory operating procedures, to ensure validity of results.
stable patients with
females (58.7%). The mean age in the study population was 19.7±5.5 years
youngest being 13years
years. Serum ferritin
was found to be significantly elevated in 56 (70.5%)
of our study subjects while 24
SF levels and none of them had low SF.
(31.3%) who had
very high SF, above 1000ng/ml, had also been
mean of 15±8.2
blood. There was a
between SF and the number of units of blood
association between SF and age, sex or red cell parameters.
This study revealed high se
rum ferritin in majority 70.5% of our patients with SCA. None of our
patients had low SF. Very high serum ferritin, more than 1000ng/ml was observed in patients who received ≥15
units of blood over a period of five years
There was a significant associatio
n between serum ferritin levels and
number of blood transfusions.
Annual serum ferritin measurements
recommended to determine the iron status
institute prompt therapeutic measure of iron chelation.||en_US
|dc.publisher||University of Nairobi||en_US
|dc.rights||Attribution-NonCommercial-NoDerivs 3.0 United States||*
|dc.subject||Serum ferritin, sickle cell anaemia||en_US
|dc.title||Serum Ferritin Levels In Patients With Sickle Cell Anaemia At The Kenyatta National Hospital||en_US