dc.contributor.author | Ochieng, PO | |
dc.contributor.author | McLigeyo, SO | |
dc.contributor.author | Amayo, EO | |
dc.contributor.author | Kayima, JK | |
dc.contributor.author | Omonge, EO | |
dc.date.accessioned | 2013-02-19T14:17:11Z | |
dc.date.issued | 2009 | |
dc.identifier.citation | East African Medical Journal | en |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/10349 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/pubmed/21644414 | |
dc.description.abstract | Objectives: To describe the incidence of renal dysfunction, hypokalaemia and hypomagnesaemia in AIDS patients with cryptococcal meningitis and on amphotericin B treatment. Secondary objective was to determine all-cause mortality in the same group. Design: Prospective, observational study.
Setting: Kenyatta National Hospital (KNH), Nairobi, Kenya.
Subjects: Seventy consecutive patients with AIDS and cryptococcal meningitis on amphotericin B.
Results: About 58.6% of the patients had at least 100% rise in the creatinine level. Thirty eight point six per cent of patients experienced a rise in serum creatinine of at least 50%. Ninty three per cent of the patients developed hypokalaemia and 80% had hypomagnesaemia at trough magnesium level. Only 54.3% of patients completed the intended 14-day treatment. Thirty point five per cent of patients died within the two week follow-up period.
Conclussion: The incidences of amphotericin B associated nephrotoxicity, hypokalemia and hypomagnesaemia were high in this studied population. | en |
dc.language.iso | en | en |
dc.relation.ispartofseries | Vol. 86 No.9; | |
dc.title | Nephrotoxicity of amphotericin b in the treatment of cryptococcal meningitis in acquired immunodeficiency syndrome patients | en |
dc.type | Article | en |
local.publisher | Department of Clinical Medicine and Therapeutics, College of Health Sciences, University of Nairobi | en |