• Login
    View Item 
    •   UoN Digital Repository Home
    • Journal Articles
    • Faculty of Health Sciences (FHS)
    • View Item
    •   UoN Digital Repository Home
    • Journal Articles
    • Faculty of Health Sciences (FHS)
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Antimalarial activity of ajuga remota benth (Labiatae) and caesalpinia iolkensii harms (Caesalpiniaceae)

    Thumbnail
    View/Open
    ABSTRACT..pdf (9.816Kb)
    Date
    2000
    Author
    Kuria, K A M
    Coster, S De
    Muriuki, G
    Masengo, W
    Kibwage, IO
    Hoogmartens, J
    Laekeman, G M
    Type
    Article
    Language
    en
    Metadata
    Show full item record

    Abstract
    Field trips to herbalists' practices in an area about 200 miles around Nairobi (Kenya) enabled us to make a list of medicinal plant species preferentially used to treat malaria. Ajuga remota and Caesalpinia oolkensii were further investigated as being the most frequently used species. Aqueous decoctions, ethanol macerates, and petroleum ether, methanol and water Soxhlet extracts of these plants were further tested for their in vitro antimalarial properties in a chloroquine sensitive (FCA/20GHA) and resistant (W2) strain of Plasmodium [alciparum. The activity was assessed by the parasite lactate dehydrogenase (pLDH) assay method. There was a concentration-dependent inhibition by the vegetal extracts of both plants. The ICso of the most active A. remota extract (ethanol macerate) was 55 and 57 j.!g/ml against FCA/20GHA and W2, respectively. For C. »olkensii, it was the Soxhlet-water extract which was most active against FCA/20GHA with an IC50 of 404 flgJml while the petroleum ether extract exhibited the most activity against W2 with an IC50 of 250 flg/ml. Further phytochemical work is being done in order to identify the active principles. © 2001 Elsevier Science Ireland Ltd. All rights reserved.
    URI
    http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/10360
    Citation
    Journal of Ethnopharmacology 74 (2001) 141-148
    Subject
    In vitro antiplasmodial activity
    Ajuga remota;
    Caesalpinia colkensii;
    Medicinal plants;
    Kenya;
    Herbalists' practice
    Collections
    • Faculty of Health Sciences (FHS) [10080]

    Copyright © 2019 
    University of Nairobi Library
    | UoN Quality Policy | Send Feedback
     

    Browse

    All of UoN Digital RepositoryCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

    My Account

    LoginRegister

    Copyright © 2019 
    University of Nairobi Library
    | UoN Quality Policy | Send Feedback