dc.contributor.author | Amayo, EO | |
dc.contributor.author | Kayima, JK | |
dc.contributor.author | Joshi, MD | |
dc.date.accessioned | 2013-02-20T06:50:34Z | |
dc.date.issued | 2002 | |
dc.identifier.citation | East African Medical Journal. | en |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/10377 | |
dc.description.abstract | Objective: To determine platelet abnormalities in patients with meningococcal meningitis. Design: Case control study. Subjects: Fifty seven cases of meningococcal meningitis based on a cerebrospinal fluid gram stain for gram negative diplodocus or positive culture were recruited. Fifty-seven controls matched for age and sex were also recruited. The following platelet functions tests were performed; platelet counts, platelet adhesiveness, platelet aggregation and clot retraction. Results: Fifty seven patients (41 males and 16 females) with meningococcal meningitis were studied. Their mean age was 25.5 ± 8.32 years with a range of 15 to 45 years. Five patients had purpura, four peripheral gangrene, eight conjunctival hemorrhages and one was in shock. There was a statistical significant difference in the platelet aggregation and clot retraction between the patients and controls at p-values of 0.0001 and 0.0002 respectively. There was no significant difference in the platelet count and adhesiveness between the patients and the controls at a p-value of 0.203 and 0.22 respectively. No association was found between the platelet functions and the clinical presentations. Conclusion: Patients with meningococcal meningitis have abnormalities in the platelet functions mainly in aggregation and adhesiveness | en |
dc.language.iso | en | en |
dc.relation.ispartofseries | Vol. 79 No 8; | |
dc.title | Platelet functions in patients with meningococcal meningitis at the Kenyatta National Hospital, Nairobi | en |
dc.type | Article | en |
local.publisher | Department of Medicine. College of Health Sciences. University of Nairobi. | en |