Suppression of nociception by Ocimum masaiense root extract involves
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Date
2011Author
Mwangi, Peter Waweru
Wambugu, Stanley Nderitu
Kariuki, David Kinuthia
Mbugua, Paul Mungai
Kanui, Titus Ikusyia
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
The members of genus Ocimum find wide application in traditional medicine. The
current study was undertaken to evaluate the probable mechanisms of antinociceptive
action of chloroform/ethanol extracts of Ocimum masaiense roots. The extract
was prepared by soxhlet extraction. The mechanism of action experiments involved
administration of various blockers along with the extract in the formalin test. Data
was analyzed using Kruksal Wallis test. The extract possessed significant antiknociceptive
activity in the formalin test. Atropine, enhanced while Ketamine,
Capsaicin and Naloxone significantly inhibited the antinociceptive activity in the
early phase. Only capsaicin had a significant inhibitory effect on the antinociceptive
activity of the extract in the late phase among the substances tested. Based on
the findings it is postulated that the extract mediates its antinociceptive activity via
a complex interplay of various neurotransmitter syste-ms which may be mediated
both centrally and peripherally.
Citation
Phytopharmacology 2011, 1(5) 148-159Publisher
Faculty of Veterinary Medicine