dc.contributor.author | Mwangi, Peter Waweru | |
dc.contributor.author | Wambugu, Stanley Nderitu | |
dc.contributor.author | Kariuki, David Kinuthia | |
dc.contributor.author | Mbugua, Paul Mungai | |
dc.contributor.author | Kanui, Titus Ikusyia | |
dc.date.accessioned | 2013-02-20T07:24:07Z | |
dc.date.issued | 2011 | |
dc.identifier.citation | Phytopharmacology 2011, 1(5) 148-159 | en |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/10391 | |
dc.description.abstract | The members of genus Ocimum find wide application in traditional medicine. The
current study was undertaken to evaluate the probable mechanisms of antinociceptive
action of chloroform/ethanol extracts of Ocimum masaiense roots. The extract
was prepared by soxhlet extraction. The mechanism of action experiments involved
administration of various blockers along with the extract in the formalin test. Data
was analyzed using Kruksal Wallis test. The extract possessed significant antiknociceptive
activity in the formalin test. Atropine, enhanced while Ketamine,
Capsaicin and Naloxone significantly inhibited the antinociceptive activity in the
early phase. Only capsaicin had a significant inhibitory effect on the antinociceptive
activity of the extract in the late phase among the substances tested. Based on
the findings it is postulated that the extract mediates its antinociceptive activity via
a complex interplay of various neurotransmitter syste-ms which may be mediated
both centrally and peripherally. | en |
dc.language.iso | en | en |
dc.subject | Ocimum masaiense | en |
dc.subject | Pain | en |
dc.subject | Mechanism of action | en |
dc.title | Suppression of nociception by Ocimum masaiense root extract involves | en |
dc.type | Article | en |
local.publisher | Faculty of Veterinary Medicine | en |