Estrogenic and anti-Inflammatory activities of a steroidal indoxyl

dc.contributor.author	Kamau, FN
dc.contributor.author	Kibwage, IO
dc.contributor.author	Muriuki, G
dc.contributor.author	Guantai, AN
dc.contributor.author	Hoogmartens, J
dc.contributor.author	Roets, E
dc.contributor.author	Govaerts, C
dc.contributor.author	Chepkwony, H
dc.contributor.author	Busson, R
dc.date.accessioned	2013-02-20T07:39:21Z
dc.date.issued	2002
dc.identifier.citation	East and Central African Journal of Pharmaceutical Sciences Vol. 5 (2002) 44 - 48	en
dc.identifier.uri	http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/10394
dc.description.abstract	The estrogenic and anti-inflammatory activities of 3-methoxy 16,17-seco16-norestra 1,3,5-trien-15-(2'-indoxyliden )-17~oic acid is reported. After' intraperitoneal administration, the dose of this compound required to reduce swelling of the rat paw by 50%(EOso) was 14.1mg/kg using 'the carrageenan-induced rat paw oedema anti-¬inflammatory assay method.indomethacin had an EOso of 3.2 m~ in this assay while dexamethasone had an EOso of l. 7 mg/kg. The estrogenic activity of the compound after intramuscular administration in rats was 0.72 relative to diethylstilbestrol, when the two compounds were assayed at three dose levels of 1.0, 0.3 and 0.1 mg/kg.	en
dc.language.iso	en	en
dc.subject	Steroidal indoxyl,	en
dc.subject	Synthesis,	en
dc.subject	Estrogenic,	en
dc.subject	Anti-inflammatory	en
dc.title	Estrogenic and anti-Inflammatory activities of a steroidal indoxyl	en
dc.type	Article	en