dc.contributor.author | Matemo, D | |
dc.contributor.author | Kinuthia, J | |
dc.contributor.author | John, F | |
dc.contributor.author | Chung, M | |
dc.contributor.author | Farquhar, C | |
dc.contributor.author | Stewart, G John | |
dc.contributor.author | Kiarie, J | |
dc.date.accessioned | 2013-02-20T08:07:39Z | |
dc.date.issued | 2008 | |
dc.identifier.citation | International Journal of STD & AIDS Volume 20 November 2009 | en |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/10412 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/pubmed/19875832 | |
dc.description.abstract | Summary: The sensitivity and specificity of rapid HIV-1 tests may be altered during pregnancy and postpartum. We conducted a
study to determine the prevalence and correlates of false-positive Abbott DetermineTM and false-negative Uni-GoldTM rapid HIV-1
test results among antenatal and postnatal mothers attending a primary care clinic in Nairobi, Kenya. Mothers were tested for HIV-1
using Abbott DetermineTM and non-reactive results were considered HIV-1 antibody negative. Reactive samples by Determine were
re-tested by Uni-GoldTM. Vironostika HIV-1 and Uni-FORM II Enzyme-linked immunosorbent assays were used to confirm samples
that had positive Abbott DetermineTM and negative Uni-GoldTM. Among 2311 women who accepted HIV-1 testing, 1238 (54%) were
tested antenatallyand 1073 (46%) were tested postnatally. Of tested women, 274 (12%) women were reactive by Abbott DetermineTM
and on retesting with Uni-GoldTM 30 (11%) had indeterminate results. The prevalence of indeterminate results was significantly higher
in antenatal women than in postnatal women (2% versus 1%,P¼ 0.03). In conclusion, indeterminate rapid HIV-1 test results are more
common in the antenatal period and appropriate safeguards to confirm HIV-1 infection status should be implemented in antenatal
programmes. | en |
dc.language.iso | en | en |
dc.subject | Indeterminate | en |
dc.subject | HIV | en |
dc.subject | Rapid | en |
dc.subject | ELISA | en |
dc.subject | test | en |
dc.title | Indeterminate rapid HIV-1 test results among antenatal and postnatal mothers | en |
dc.type | Article | en |
local.publisher | Department of Obstetric and Gynaecology, University of Nairobi, Kenya | en |