| dc.contributor.author | Amugune, BK | |
| dc.contributor.author | Thoithi, GN | |
| dc.contributor.author | Kibwage, IO | |
| dc.date.accessioned | 2013-02-20T09:50:52Z | |
| dc.date.issued | 2006 | |
| dc.identifier.citation | East and Central African Journal of Pharmaceutical Sciences Vol. 9 (2006) 19 - 25 | en |
| dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/10426 | |
| dc.description.abstract | A liquid chromatographic method for the simultaneous assay of four anticonvulsant drugs, phenobarbitone, ethosuximide, phenytoin and carbamazepine on a polystyrene-divinyl benzene column is described. The method was developed by the systematic study of different types of co-polymer materials, type and concentration of organic modifiers, buffer pH and concentration and column temperature. A PLRP-S 100 A 8 um column maintained at 60°C and a mobile phase consisting of acetonitrile-tert-butanol-phosphate buffer (pH 7.6, 0.2 M)-water (25:5:10:60, v/v) were used. The flow rate was 1 ml/min with ultraviolet detection at 220 nm. The method has been validated and used for the analysis of raw materials, finished products and dissolution studies of the drugs | en |
| dc.language.iso | en | en |
| dc.subject | Liquid chromatography, | en |
| dc.subject | Co-polymer column, | en |
| dc.subject | Phenobarbitone, | en |
| dc.subject | Ethosuximide, | en |
| dc.subject | Phenytoin, | en |
| dc.subject | Carbamazepine | en |
| dc.title | Liquid chromatographic analysis of phenobarbitone, ethosuximide, phenytoin and carbamazepine on a polystyrene-divinyl benzene column | en |
| dc.type | Article | en |
| local.publisher | Department of Pharmaceutical Chemistry, School of Pharmacy, University of Nairobi | en |
