dc.contributor.author | Kamau, FN | |
dc.contributor.author | Kibwage, IO | |
dc.contributor.author | Muriuki, G | |
dc.contributor.author | Guantai, AN | |
dc.contributor.author | Chepkwony, H | |
dc.contributor.author | Hoogmartens, J | |
dc.contributor.author | Roets, E. | |
dc.contributor.author | Busson, R | |
dc.date.accessioned | 2013-02-20T10:13:22Z | |
dc.date.issued | 2006 | |
dc.identifier.citation | East and Central African Journal ofPhannaceutical Sciences Vol. 9 (2006) 52-57 | en |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/10433 | |
dc.description.abstract | Three steroidal indoxyls, 3-oxo-16,17-seco-16;.nor-l,4-androstadien-15-(7'-methoxy-2-indoxyliden)17-oic acid, 1-(2'-indoxyliden)-2-nor-l,2-secocholestan-3~ oic acid and 1-(5'- chloro-2-indoxyliden)-2-nor-l,2-secocholestan-3-oic acid were synthesized and screened for anti-inflammatory activity. Their pK. values were also determined using a solubility method. The first compound, 3-oxo-16,17- seco-16-nor-l ,4-androstadien-15-(7' -methoxy-2-indoxyliden) 17 -oic acid, had an EDso value of 15.3 mg/kg and a pK. of 7.09. The cholestane derivative, 1-(2'-indoxyliden)-2-nor-l,2-secocholestan-3-oic acid, and its chloro analogue 1-(5'-chloro-2-indoxyliden)-2-nor-l,2-secocholestan-3-oic acid had EDso values of 16.2 and 22.8 mg/kg, while their pK. values were 6.56 and 7.07, respectively, suggesting that these compounds are relatively weak acids. | en |
dc.language.iso | en | en |
dc.subject | Steroidal indoxyls, | en |
dc.subject | Pka values, | en |
dc.subject | Anti-inflammatory | en |
dc.title | Steroidal Indoxyls: Evaluation of Pk, values and anti-inflammatory activity | en |
dc.title.alternative | Evaluation of Pk, values and anti-inflammatory activity | en |
dc.type | Article | en |
local.publisher | Department of Pharmaceutical Chemistry, School of Pharmacy, University of Nairobi | en |
local.publisher | 'Department of Pharmacology and Pharmacognosy, School of Pharmacy, University of Nairobi | en |
local.publisher | National Quality Control Laboratory, | en |
local.publisher | Katholieke Universiteit Leuven, Faculteit Farmaceutische Wetenschappen, Van Evenstraat | en |