Practical therapeutics:some investigations of the toxic effects of the alkaloids extracted from Strychnos henningsii (Gilg) "muteta
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Date
1984Author
Ogeto, John O.
Juma, FD
Muriuki, G
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
The effect of alkaloids extracted from strychnos henningsii plant were studied on the normal mice following the intraperitoneal administration on the isolated innerverted skeletal muscles of the rat diaphragm as well as on local anatomic sites of the guinea pig skin.The alkaloids induced convulsions and paralysis characteristic of strychnine poisoning.The convulsions were reversible on the administration of pentobarbitone strychnos henningsii bases produced progressive blockade of the neuromuscular junction without initial stimulation.The blockade was not antagonised by physostigmine.Results of this work indicated strychnos henningsii alkanoids effects are similar to those of strychnine and not curare.we conclude that the commonly used appetiser strychnos henningsii decoction may be dangerous in overdose and suggest that incase of poisoning barbiturates could be used as antidote
URI
http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/10555http://www.ncbi.nlm.nih.gov/pubmed/6510321
Citation
East African medical journal Vol.61 No. 5 May 1984Publisher
Department of pharmacy and clinical pharmacology
Collections
- Faculty of Health Sciences (FHS) [10378]