Involvement of Autoimmunity in the Pathogenesis of Aggressive Periodontitis
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Date
2010Author
Hendler, A.
Mulli Tonnie K.
Hughes, F. J.
Perrett, D.
Bombardieri, M.
Houri-Haddad, Y.
Weiss, E. I.
Nissim, A.
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
The aim of this study was to investigate the involvement of autoimmune reactions to native and post-translationally modified extracellular matrix components in the pathogenesis of periodontitis. Sera from individuals with aggressive periodontitis (AgP, n = 25), chronic periodontitis (CP, n = 14), and gingivitis (G, n = 18) were tested for the presence of autoantibodies against: (a) native collagen type I (CI) and collagen type III (CIII); (b) CI and CIII post-translationally modified by reactive oxygen species (ROS) of the type present during inflammation; and (c) citrullinated filaggrin-derived peptides (CCP). Autoantibodies to native and ROS-modified CI and CIII as well as autoantibodies to CCP were observed exclusively in patients with AgP and not in those with CP or G. In conclusion, autoimmune reactions to native and post-translationally modified self-antigens may play a role specifically in the pathogenesis of AgP.
Citation
J Dent Res 89(12):1389-1394, 2010Publisher
London School of Medicine and Dentistry Centre for Experimental Medicine & Rheumatology, The Hebrew University-Hadassah Bone and Joint Research Unit
Description
Involvement of Autoimmunity in the Pathogenesis of Aggressive Periodontitis
Collections
- Faculty of Health Sciences (FHS) [10377]