Investigation of the kinetics of degradation of hexopyranosylated cytosine nucleosides using liquid chromatography
Date
2000Author
Thoithi, Grace N.
Schepdael, Ann Van
Busson, Roger
Janssen, Gerard
Aerschot, Arthur Van
Herdewijn, Piet
Roets, Eugene
Hoogmartens, Jos
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
Liquid chromatography was used to follow the degradation of hexopyranosylated cytosine nucleosides in buffers of acid, neutral and alkaline pH and of constant ionic strength, The compounds were found to degrade by hydrolysis to cytosine and/or by deamination to the corresponding uracil nucleosides. Degradation in acid is influenced by the number of sugar hydroxyl groups, presence of sugar double bonds and the type of anomer. Stability of some of the compounds was compared with that of related thymine nucleosides. Temperature studies support a unimolecular mechanism of hydrolysis at pH 1.22.
URI
http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/10689http://www.ncbi.nlm.nih.gov/pubmed/10772709
Citation
Nucleosides & nucleotides and Nucleic acids, 19(1&2), 189-203 (2000)Publisher
Department of Pharmaceuucal Chemistry, faculty of Pharmacy, University of Nairobi • Katholieke Universiteit Leuven, Laboratorium voor Parmaceutische Chemie en Analyse van Geneesmiddelen, Paculteit Farmaceutische Wetenschappen, Van Evenstraat
Collections
- Faculty of Health Sciences (FHS) [10377]