| dc.contributor.author | Yaouba, Souaibou | |
| dc.contributor.author | Valkonen, Arto | |
| dc.contributor.author | Coghi, Paolo | |
| dc.contributor.author | Jiaying, Gao | |
| dc.contributor.author | Guantai, Eric M. | |
| dc.contributor.author | Derese, Solomon | |
| dc.contributor.author | Vincent, K. W. Wong | |
| dc.contributor.author | Erdélyi, Máté | |
| dc.contributor.author | Yenesew, Abiy | |
| dc.date.accessioned | 2019-08-14T08:47:37Z | |
| dc.date.available | 2019-08-14T08:47:37Z | |
| dc.date.issued | 2018 | |
| dc.identifier.citation | Yaouba S, Valkonen A, Coghi P, Gao J, Guantai EM, Derese S, Wong VKW, Erdélyi Máté, Yenesew A. "Crystal Structures and Cytotoxicity of ent-Kaurane-Type Diterpenoids from Two Aspilia Species." Molecules. 2018;23(12):31-99. | en_US |
| dc.identifier.uri | https://profiles.uonbi.ac.ke/ayenesew/publications/crystal-structures-and-cytotoxicity-ent-kaurane-type-diterpenoids-two-aspilia- | |
| dc.identifier.uri | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321058/pdf/molecules-23-03199.pdf | |
| dc.identifier.uri | http://erepository.uonbi.ac.ke/handle/11295/106943 | |
| dc.description.abstract | A phytochemical investigation of the roots ofAspilia plurisetaled to the isolationofent-kaurane-type diterpenoids and additional phytochemicals (1–23).The structures ofthe isolated compounds were elucidated based on Nuclear Magnetic Resonance (NMR)spectroscopic and mass spectrometric analyses. The absolute configurations of seven of theent-kaurane-type diterpenoids (3–6,6b, 7and8) were determined by single crystal X-raydiffraction studies.Eleven of the compounds were also isolated from the roots and theaerial parts ofAspilia mossambicensis. The literature NMR assignments for compounds1and5were revised.In a cytotoxicity assay, 12α-methoxy-ent-kaur-9(11),16-dien-19-oic acid (1)(IC50= 27.3±1.9μM) and 9β-hydroxy-15α-angeloyloxy-ent-kaur-16-en-19-oic acid (3) (IC50=24.7±2.8μM) were the most cytotoxic against the hepatocellular carcinoma (Hep-G2) cell line,while 15α-angeloyloxy-16β,17-epoxy-ent-kauran-19-oic acid (5) (IC50= 30.7±1.7μM) was the mostcytotoxic against adenocarcinomic human alveolar basal epithelial (A549) cells. | en_US |
| dc.language.iso | en | en_US |
| dc.publisher | University of Nairobi | en_US |
| dc.subject | Asteraceae;Aspilia pluriseta;Aspilia mossambicensis;ent-kaurane diterpenoid; X-ray crystalstructure; cytotoxicity | en_US |
| dc.title | Crystal Structures and Cytotoxicity ofent-Kaurane-TypeDiterpenoids from TwoAspiliaSpecies | en_US |
| dc.type | Article | en_US |
